Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy
The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, New Zealand white ra...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2011/204501 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554911458394112 |
|---|---|
| author | Chiao-Shih Tseng Shih-Ming Chen Shu-Chen Chien Kuang-Yang Hsu |
| author_facet | Chiao-Shih Tseng Shih-Ming Chen Shu-Chen Chien Kuang-Yang Hsu |
| author_sort | Chiao-Shih Tseng |
| collection | DOAJ |
| description | The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, New Zealand white rabbits were used in this study. The plasma concentrations of PAH and inulin were determined by validated HPLC methods. After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate nephrotoxicity on the 7th day. Significant tubulointerstitial damage to kidney specimens was found, but there were no remarkable glomerular changes. Clearance rates of PAH and inulin both significantly decreased in AANa-treated rabbits. In addition, there was a significant correlation among the degree of tubulointerstitial changes and PK parameters of PAH after AANa administration, but no correlation was noted with the PKs of inulin. With mild to moderate AAN in rabbits, the renal plasma flow significantly decreased by 55%, and the glomerular filtration rate also significantly decreased by 85%. In conclusion, major renal lesions were found on proximal tubules after AANa administration. The PKs of PAH and inulin significantly changed, and kidney functions, including the RPF and GFR, were reduced. |
| format | Article |
| id | doaj-art-766037f1354d45afbb24823b4e91b690 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-766037f1354d45afbb24823b4e91b6902025-02-03T05:50:09ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422011-01-01201110.1155/2011/204501204501Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid NephropathyChiao-Shih Tseng0Shih-Ming Chen1Shu-Chen Chien2Kuang-Yang Hsu3College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11014, TaiwanCollege of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11014, TaiwanCollege of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11014, TaiwanCollege of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 11014, TaiwanThe characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, New Zealand white rabbits were used in this study. The plasma concentrations of PAH and inulin were determined by validated HPLC methods. After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate nephrotoxicity on the 7th day. Significant tubulointerstitial damage to kidney specimens was found, but there were no remarkable glomerular changes. Clearance rates of PAH and inulin both significantly decreased in AANa-treated rabbits. In addition, there was a significant correlation among the degree of tubulointerstitial changes and PK parameters of PAH after AANa administration, but no correlation was noted with the PKs of inulin. With mild to moderate AAN in rabbits, the renal plasma flow significantly decreased by 55%, and the glomerular filtration rate also significantly decreased by 85%. In conclusion, major renal lesions were found on proximal tubules after AANa administration. The PKs of PAH and inulin significantly changed, and kidney functions, including the RPF and GFR, were reduced.http://dx.doi.org/10.1155/2011/204501 |
| spellingShingle | Chiao-Shih Tseng Shih-Ming Chen Shu-Chen Chien Kuang-Yang Hsu Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy Advances in Pharmacological Sciences |
| title | Pharmacokinetics of p-Aminohippuric Acid and Inulin
in Rabbits with Aristolochic Acid Nephropathy |
| title_full | Pharmacokinetics of p-Aminohippuric Acid and Inulin
in Rabbits with Aristolochic Acid Nephropathy |
| title_fullStr | Pharmacokinetics of p-Aminohippuric Acid and Inulin
in Rabbits with Aristolochic Acid Nephropathy |
| title_full_unstemmed | Pharmacokinetics of p-Aminohippuric Acid and Inulin
in Rabbits with Aristolochic Acid Nephropathy |
| title_short | Pharmacokinetics of p-Aminohippuric Acid and Inulin
in Rabbits with Aristolochic Acid Nephropathy |
| title_sort | pharmacokinetics of p aminohippuric acid and inulin in rabbits with aristolochic acid nephropathy |
| url | http://dx.doi.org/10.1155/2011/204501 |
| work_keys_str_mv | AT chiaoshihtseng pharmacokineticsofpaminohippuricacidandinulininrabbitswitharistolochicacidnephropathy AT shihmingchen pharmacokineticsofpaminohippuricacidandinulininrabbitswitharistolochicacidnephropathy AT shuchenchien pharmacokineticsofpaminohippuricacidandinulininrabbitswitharistolochicacidnephropathy AT kuangyanghsu pharmacokineticsofpaminohippuricacidandinulininrabbitswitharistolochicacidnephropathy |