Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

Changes in epigenetic processes such as histone acetylation are proposed as key events influencing cancer cell function and the initiation and progression of pediatric brain tumors. Valproic acid (VPA) is an antiepileptic drug that acts partially by inhibiting histone deacetylases (HDACs) and could...

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Main Authors: Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Cells
Subjects:
valproic acid
<i>MYC</i>
<i>TP53</i>
stemness
differentiation
medulloblastoma
Online Access:https://www.mdpi.com/2073-4409/14/2/72
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