TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma

TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma

BackgroundPancreatic cancer (PC) is a highly aggressive pancreatic malignant tumor with poor prognosis due to its complex tumor microenvironment (TME) and metastatic potential. Fibroblasts play an important role in tumor progression and metastasis by remodeling the extracellular matrix (ECM) and inf...

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Bibliographic Details
Main Authors: Qingwen Hu, Jiali Chen, Yang Liu, Haiqing Chen, Haotian Lai, Lai Jiang, Xuancheng Zhou, Shengke Zhang, Jinbang Huang, Hao Chi, Bo Li, Xiaolin Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
single-cell analysis
pancreatic ductal adenocarcinoma
immunotherapy
migrasomes
TSPAN4
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1594879/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1594879/full

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