Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials
The objective: to study morphological changes in tissues after implantation of a bioresorbable material synthesized on the basis of polylactide (PLA) and polycaprolactone (PCL) in various ratios.Subjects and Methods. Laboratory animals Chinchilla lanigera (n = 12) underwent intrapleural implantation...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2023-03-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1708 |
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| author | G. A. Demyashkin T. K. Tokaev A. S. Bikbaev M. V. Sinitsyn T. E. Grigoryev Yu. D. Zagoskin |
| author_facet | G. A. Demyashkin T. K. Tokaev A. S. Bikbaev M. V. Sinitsyn T. E. Grigoryev Yu. D. Zagoskin |
| author_sort | G. A. Demyashkin |
| collection | DOAJ |
| description | The objective: to study morphological changes in tissues after implantation of a bioresorbable material synthesized on the basis of polylactide (PLA) and polycaprolactone (PCL) in various ratios.Subjects and Methods. Laboratory animals Chinchilla lanigera (n = 12) underwent intrapleural implantation with 2% PLA/PCL 1/1 and 4% PLA/PCL 1/3 materials. Morphometric assessment was carried out in14 and 28 weeks, the animals were withdrawn from the experiment by an anesthetic overdosing.Results. When studying tissues adjacent to the implant regardless of differences in its composition, similar morphological signs were observed. A fibrous capsule formed around the implants, and it was more pronounced in 4% of PLA/PCL 1/3. In the structure of the implants, we noted the growth of loose and dense unformed fibrous connective tissue with blood vessels with a significant replacement of the bioresorbable polymer material (by 2/3). Lymphocytes, plasma cells, single macrophages, and multinucleated cells were predominantly located at the implant/tissue interface. In all studied samples, no necrosis was observed in the implantation bed and surrounding tissue.Conclusion. The data obtained confirm the biosafety of biomaterials and demonstrate the potential for their use in surgical treatment of humans. |
| format | Article |
| id | doaj-art-75e4d63b0a8d4146b79d5655e883350c |
| institution | DOAJ |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-75e4d63b0a8d4146b79d5655e883350c2025-08-20T03:02:41ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062023-03-011011485410.58838/2075-1230-2023-101-1-48-541703Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic MaterialsG. A. Demyashkin0T. K. Tokaev1A. S. Bikbaev2M. V. Sinitsyn3T. E. Grigoryev4Yu. D. Zagoskin5I.M. Sechenov First Moscow State Medical UniversityNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of Health; Pirogov Russian National Research Medical UniversityKurchatov Institute National Research CenterKurchatov Institute National Research CenterThe objective: to study morphological changes in tissues after implantation of a bioresorbable material synthesized on the basis of polylactide (PLA) and polycaprolactone (PCL) in various ratios.Subjects and Methods. Laboratory animals Chinchilla lanigera (n = 12) underwent intrapleural implantation with 2% PLA/PCL 1/1 and 4% PLA/PCL 1/3 materials. Morphometric assessment was carried out in14 and 28 weeks, the animals were withdrawn from the experiment by an anesthetic overdosing.Results. When studying tissues adjacent to the implant regardless of differences in its composition, similar morphological signs were observed. A fibrous capsule formed around the implants, and it was more pronounced in 4% of PLA/PCL 1/3. In the structure of the implants, we noted the growth of loose and dense unformed fibrous connective tissue with blood vessels with a significant replacement of the bioresorbable polymer material (by 2/3). Lymphocytes, plasma cells, single macrophages, and multinucleated cells were predominantly located at the implant/tissue interface. In all studied samples, no necrosis was observed in the implantation bed and surrounding tissue.Conclusion. The data obtained confirm the biosafety of biomaterials and demonstrate the potential for their use in surgical treatment of humans.https://www.tibl-journal.com/jour/article/view/1708tuberculosisimplantsbiopolymersbiosafety |
| spellingShingle | G. A. Demyashkin T. K. Tokaev A. S. Bikbaev M. V. Sinitsyn T. E. Grigoryev Yu. D. Zagoskin Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials Туберкулез и болезни лёгких tuberculosis implants biopolymers biosafety |
| title | Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials |
| title_full | Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials |
| title_fullStr | Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials |
| title_full_unstemmed | Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials |
| title_short | Morphological and Functional Characteristics of the Microenvironment After Pleural Implantation of Biosynthetic Materials |
| title_sort | morphological and functional characteristics of the microenvironment after pleural implantation of biosynthetic materials |
| topic | tuberculosis implants biopolymers biosafety |
| url | https://www.tibl-journal.com/jour/article/view/1708 |
| work_keys_str_mv | AT gademyashkin morphologicalandfunctionalcharacteristicsofthemicroenvironmentafterpleuralimplantationofbiosyntheticmaterials AT tktokaev morphologicalandfunctionalcharacteristicsofthemicroenvironmentafterpleuralimplantationofbiosyntheticmaterials AT asbikbaev morphologicalandfunctionalcharacteristicsofthemicroenvironmentafterpleuralimplantationofbiosyntheticmaterials AT mvsinitsyn morphologicalandfunctionalcharacteristicsofthemicroenvironmentafterpleuralimplantationofbiosyntheticmaterials AT tegrigoryev morphologicalandfunctionalcharacteristicsofthemicroenvironmentafterpleuralimplantationofbiosyntheticmaterials AT yudzagoskin morphologicalandfunctionalcharacteristicsofthemicroenvironmentafterpleuralimplantationofbiosyntheticmaterials |