Impact of CD3 expression on outcome in pediatric anaplastic large cell lymphoma

Impact of CD3 expression on outcome in pediatric anaplastic large cell lymphoma

BackgroundAnaplastic large cell lymphoma (ALCL) constitutes 10-15% of childhood non-Hodgkin lymphoma. EFS is 70% and currently 80% with the additional of targeted agents such as CD30 directed conjugated monoclonal antibody brentuximab or ALK inhibitors such as crizotinib. Expression of CD3, a T-cell...

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Bibliographic Details
Main Authors: Ahmed Salah, Hanafy Hafez, Samah Semary, Eman Naguib Khorshed, Sonia Soliman, Iman Zaky, Shahenda M. Shahin, Leslie Lehmann, Alaa ElHaddad
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
CD3
survival
pediatric anaplastic large cell lymphoma
ALK
outcome
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1569370/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1569370/full

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