Metformin Protective Effects in LPS-Induced Alzheimer's Disease Mice Model: NO-cGMP-KATP Pathway Involvement

Metformin Protective Effects in LPS-Induced Alzheimer's Disease Mice Model: NO-cGMP-KATP Pathway Involvement

This project has studied the effects of metformin on cognition impairment, depression, hyperalgesia, stress oxidative and neuroinflammation in a rodent Alzheimer's disease (AD) model created via LPS (lipopolysaccharide). For defining possible mechanisms, the NO/cGMP/KATP pathway roleplay was co...

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Bibliographic Details
Main Authors: Mojtaba Dolatshahi, Ali Khorsandinezhad, Behnam Ghorbanzadeh, Yousef Paridar, Donya Nazarinia
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2025-05-01
Series:Acta Medica Iranica
Subjects:
Metformin
Lipopolysaccharides (LPS)
Cognition
Oxidative stress
Depression
Hyperalgesia
Online Access:https://acta.tums.ac.ir/index.php/acta/article/view/11284
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https://acta.tums.ac.ir/index.php/acta/article/view/11284

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