Bifurcation analysis of HIV-1 infection model with cell-to-cell transmission and immune response delay

A within-host viral infection model with both virus-to-cell and cell-to-cell transmissions and time delay in immune response is investigated. Mathematical analysis shows that delay may destabilize the infected steady state and lead to Hopf bifurcation. Moreover, the direction of the Hopf bifurcati...

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Bibliographic Details
Main Authors: Jinhu Xu, Yicang Zhou
Format: Article
Language:English
Published: AIMS Press 2015-11-01
Series:Mathematical Biosciences and Engineering
Subjects:
Online Access:https://www.aimspress.com/article/doi/10.3934/mbe.2015006
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