Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3

Summary: Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. Her...

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Main Authors: Ling Ye, Shengqi Shen, Qiankun Mao, Hui Lu, Haiying Liu, Pinggen Zhang, Zetan Jiang, Wenhao Ma, Yuchen Sun, Yiyang Chu, Zilong Zhou, Rui Liu, Jian Li, Shi-ting Li, Ping Gao, Huafeng Zhang
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472500021X
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