A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing

A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing

Hepatocellular Carcinoma (HCC) is the most common form of primary liver cancer, with cirrhosis being its strongest risk factor. Interestingly, an increasing number of HCC cases is also observed without cirrhosis. We developed an HCC model via intrasplenic injection of highly tumorigenic HCC cells, w...

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Bibliographic Details
Main Authors: Karina Benderski, Paul Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli, Fabian Kiessling, Matthias Bros, Mustafa Diken, Stephan Grabbe, Jörn M. Schattenberg, Twan Lammers, Alexandros Marios Sofias, Leonard Kaps
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
Hepatocellular carcinoma (HCC)
Liver cancer
Cirrhosis
Fibrosis
Nonalcoholic fatty liver disease
Nonalcoholic steatohepatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182400505X
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