Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records

Exploring Effects of Age at the Onset of Myopia on Multiple Diseases Using Electronic Health Records

Purpose: To examine whether genetic predisposition to age at the onset of myopia is associated with the development of future diseases. Design: Mendelian randomization phenome-wide association study (MR-PheWAS) from the UK Biobank. Participants: A polygenic risk score (PRS) for age at the onset of m...

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Main Authors: Xiayin Zhang, PhD, Shan Wang, MD, Yu Huang, PhD, Yanjie Xie, PhD, Ishith Seth, MD, Gabriella Bulloch, MD, Chunran Lai, MD, Yijun Hu, PhD, Xianwen Shang, PhD, Mingguang He, PhD, Zhuoting Zhu, PhD, Honghua Yu, PhD
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ophthalmology Science
Subjects:
Age at myopia onset
Phenome-wide association study
Mendelian randomization
Myopia-related comorbidities
Online Access:http://www.sciencedirect.com/science/article/pii/S2666914525001174
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