Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine
Objective. The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), inter...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/343268 |
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| author | Hala O. El-Mesallamy Nadia M. Hamdy Adel K. El-Etriby Eman F. Wasfey |
| author_facet | Hala O. El-Mesallamy Nadia M. Hamdy Adel K. El-Etriby Eman F. Wasfey |
| author_sort | Hala O. El-Mesallamy |
| collection | DOAJ |
| description | Objective. The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), interleukin 18 (IL-18), and fractalkine (FKN) in the early phase after acute cardiac events in different ACS subgroups. Methods. Thirty-six nondiabetic patients with ACS were compared to 12 control subjects. According to ACS diagnosis, the patients were classified into 22 patients with ST elevation myocardial infarction (STEMI) and 14 patients with non-ST elevation myocardial infarction or unstable angina (NSTEMI/UA). Blood samples were taken on day 1 (day of onset) and day 3 to measure hsCRP, IL-18, FKN, and GZB by ELISA. Results. Patients with ACS showed significantly higher GZB, IL-18, and FKN levels than the controls. STEMI group showed significantly higher GZB levels than NSTEMI/UA group. On day 3, FKN levels displayed a significant decrease, while GZB levels were significantly increased. IL-18 levels were more or less constant. GZB levels were positively correlated with IL-18 (, ) and FKN (, ). Conclusions. Unlike IL-18 and FKN, plasma GZB may be a marker of ACS disease severity. |
| format | Article |
| id | doaj-art-74f18bf3f76c4249aab1b3fac3eb91cf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-74f18bf3f76c4249aab1b3fac3eb91cf2025-02-03T01:03:45ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/343268343268Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and FractalkineHala O. El-Mesallamy0Nadia M. Hamdy1Adel K. El-Etriby2Eman F. Wasfey3Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, EgyptBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, EgyptCardiology Department, Faculty of Medicine, Ain Shams University, Abassia, Cairo 11566, EgyptBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo 11566, EgyptObjective. The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), interleukin 18 (IL-18), and fractalkine (FKN) in the early phase after acute cardiac events in different ACS subgroups. Methods. Thirty-six nondiabetic patients with ACS were compared to 12 control subjects. According to ACS diagnosis, the patients were classified into 22 patients with ST elevation myocardial infarction (STEMI) and 14 patients with non-ST elevation myocardial infarction or unstable angina (NSTEMI/UA). Blood samples were taken on day 1 (day of onset) and day 3 to measure hsCRP, IL-18, FKN, and GZB by ELISA. Results. Patients with ACS showed significantly higher GZB, IL-18, and FKN levels than the controls. STEMI group showed significantly higher GZB levels than NSTEMI/UA group. On day 3, FKN levels displayed a significant decrease, while GZB levels were significantly increased. IL-18 levels were more or less constant. GZB levels were positively correlated with IL-18 (, ) and FKN (, ). Conclusions. Unlike IL-18 and FKN, plasma GZB may be a marker of ACS disease severity.http://dx.doi.org/10.1155/2013/343268 |
| spellingShingle | Hala O. El-Mesallamy Nadia M. Hamdy Adel K. El-Etriby Eman F. Wasfey Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine Mediators of Inflammation |
| title | Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine |
| title_full | Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine |
| title_fullStr | Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine |
| title_full_unstemmed | Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine |
| title_short | Plasma Granzyme B in ST Elevation Myocardial Infarction versus Non-ST Elevation Acute Coronary Syndrome: Comparisons with IL-18 and Fractalkine |
| title_sort | plasma granzyme b in st elevation myocardial infarction versus non st elevation acute coronary syndrome comparisons with il 18 and fractalkine |
| url | http://dx.doi.org/10.1155/2013/343268 |
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