Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry
The present research work discusses the development and validation of a UV spectrophotometric method for Exemestane. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Exemestane in Tablet dosage form. The optimum conditions for the analysis of the...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/782738 |
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| author | S. Angalaparameswari V. S. Thiruvengadarajan N. Amruth Kumar M. Kutumbarao S. Ramkanth C. Madhusudhanachetty |
| author_facet | S. Angalaparameswari V. S. Thiruvengadarajan N. Amruth Kumar M. Kutumbarao S. Ramkanth C. Madhusudhanachetty |
| author_sort | S. Angalaparameswari |
| collection | DOAJ |
| description | The present research work discusses the development and validation of a UV spectrophotometric method for Exemestane. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Exemestane in Tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 246 nm. The percentage recovery of Exemestane was in the 98.7±0.4. Beers law was obeyed in the concentration range of 2-14 µg/mL. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.05954x+0.0000 with r2 of 0.9938 was obtained. Validation was performed according to ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of Exemestane in tablet formulation for quality control purposes. |
| format | Article |
| id | doaj-art-74cb4ffc1a1b4511b7f08b0f66a9e47c |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-74cb4ffc1a1b4511b7f08b0f66a9e47c2025-02-03T05:51:28ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01942068207310.1155/2012/782738Analytical Method Development and Validation of Exemestane Tablet by UV SpectrophotometryS. Angalaparameswari0V. S. Thiruvengadarajan1N. Amruth Kumar2M. Kutumbarao3S. Ramkanth4C. Madhusudhanachetty5Department of Pharmaceutical Analysis, Annamacharya College of Pharmacy Rajampet—516 126, Kadapa district, Andhra Pradesh, IndiaDepartment of Pharmaceutical Analysis, Annamacharya College of Pharmacy Rajampet—516 126, Kadapa district, Andhra Pradesh, IndiaDepartment of Pharmaceutical Analysis, Annamacharya College of Pharmacy Rajampet—516 126, Kadapa district, Andhra Pradesh, IndiaDepartment of Pharmaceutical Analysis, Annamacharya College of Pharmacy Rajampet—516 126, Kadapa district, Andhra Pradesh, IndiaDepartment of Pharmaceutical Analysis, Annamacharya College of Pharmacy Rajampet—516 126, Kadapa district, Andhra Pradesh, IndiaDepartment of Pharmaceutical Analysis, Annamacharya College of Pharmacy Rajampet—516 126, Kadapa district, Andhra Pradesh, IndiaThe present research work discusses the development and validation of a UV spectrophotometric method for Exemestane. Simple, accurate and cost efficient spectrophotometric method has been developed for the estimation of Exemestane in Tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λ max) was found to be 246 nm. The percentage recovery of Exemestane was in the 98.7±0.4. Beers law was obeyed in the concentration range of 2-14 µg/mL. Calibration curves shows a linear relationship between the absorbance and concentration. The line equation y=0.05954x+0.0000 with r2 of 0.9938 was obtained. Validation was performed according to ICH guidelines for Linearity, accuracy, precision, LOD and LOQ. The sample solution was stable up to 36 hours. The proposed method may be suitable for the analysis of Exemestane in tablet formulation for quality control purposes.http://dx.doi.org/10.1155/2012/782738 |
| spellingShingle | S. Angalaparameswari V. S. Thiruvengadarajan N. Amruth Kumar M. Kutumbarao S. Ramkanth C. Madhusudhanachetty Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry E-Journal of Chemistry |
| title | Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry |
| title_full | Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry |
| title_fullStr | Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry |
| title_full_unstemmed | Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry |
| title_short | Analytical Method Development and Validation of Exemestane Tablet by UV Spectrophotometry |
| title_sort | analytical method development and validation of exemestane tablet by uv spectrophotometry |
| url | http://dx.doi.org/10.1155/2012/782738 |
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