Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents
4-Chloro-2-oxo-2H-chromene-3-carbaldehyde (2) was reacted with different anilines in rectified spirit as solvent to yield a series of the title compounds i.e. 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2-one (3a-i). These compounds were charaterised on the basis of their spectral (IR,...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/874389 |
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| author | Shriram Bairagi Ashok Bhosale Meenakshi N. Deodhar |
| author_facet | Shriram Bairagi Ashok Bhosale Meenakshi N. Deodhar |
| author_sort | Shriram Bairagi |
| collection | DOAJ |
| description | 4-Chloro-2-oxo-2H-chromene-3-carbaldehyde (2) was reacted with different anilines in rectified spirit as solvent to yield a series of the title compounds i.e. 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2-one (3a-i). These compounds were charaterised on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 3C was found to be most active with an MIC of 15 μg /mL against all the tested organisms. |
| format | Article |
| id | doaj-art-74bdbda5adce4516a98b3c50e87ed788 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-74bdbda5adce4516a98b3c50e87ed7882025-02-03T06:44:20ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016375976210.1155/2009/874389Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial AgentsShriram Bairagi0Ashok Bhosale1Meenakshi N. Deodhar2Department of Pharmaceutical Chemistry, SGRS College of Pharmacy, Saswad, Pune-412301, IndiaDepartment of Pharmaceutical Chemistry, SGRS College of Pharmacy, Saswad, Pune-412301, IndiaDepartment of Pharmaceutical Chemistry, SGRS College of Pharmacy, Saswad, Pune-412301, India4-Chloro-2-oxo-2H-chromene-3-carbaldehyde (2) was reacted with different anilines in rectified spirit as solvent to yield a series of the title compounds i.e. 4-chloro-3-((substituted-phenylimino) methyl)-2H-chromen-2-one (3a-i). These compounds were charaterised on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 3C was found to be most active with an MIC of 15 μg /mL against all the tested organisms.http://dx.doi.org/10.1155/2009/874389 |
| spellingShingle | Shriram Bairagi Ashok Bhosale Meenakshi N. Deodhar Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents E-Journal of Chemistry |
| title | Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents |
| title_full | Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents |
| title_fullStr | Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents |
| title_full_unstemmed | Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents |
| title_short | Design, Synthesis and Evaluation of Schiff’s Bases of 4-Chloro-3-coumarin aldehyde as Antimicrobial Agents |
| title_sort | design synthesis and evaluation of schiff s bases of 4 chloro 3 coumarin aldehyde as antimicrobial agents |
| url | http://dx.doi.org/10.1155/2009/874389 |
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