APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.

APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.

Alzheimer's disease is marked by intracellular tau aggregates in the medial temporal lobe (MTL) and extracellular amyloid aggregates in the default network (DN). Here, we examined codependent structural variations between the MTL's most vulnerable structure, the hippocampus (HC), and the D...

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Main Authors: Chloé Savignac, Sylvia Villeneuve, AmanPreet Badhwar, Karin Saltoun, Kimia Shafighi, Chris Zajner, Vaibhav Sharma, Sarah A Gagliano Taliun, Sali Farhan, Judes Poirier, Danilo Bzdok
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001863&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3001863&type=printable

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