Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC

Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC

Abstract Background Integrin alpha 5 (ITGA5) was previously confirmed to be related to prognosis in several cancer types; however, its function in clear cell renal cell carcinoma (ccRCC) and how this molecule regulates tumor progression and the tumor microenvironment (TME) remain to be elucidated. M...

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Main Authors: Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cancer Cell International
Subjects:
Clear cell renal cell carcinoma
ITGA5
Biomarker
Machine learning
Tumor microenvironment
Online Access:https://doi.org/10.1186/s12935-024-03546-4
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https://doi.org/10.1186/s12935-024-03546-4

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