The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

The full-length BEND2 protein is dispensable for spermatogenesis but required for setting the ovarian reserve in mice

Infertility affects up to 12% of couples globally, with genetic factors contributing to nearly half of the cases. Advances in genomic technologies have led to the discovery of genes like Bend2, which play a crucial role in gametogenesis. In the testis, Bend2 expresses two protein isoforms: full-leng...

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Bibliographic Details
Main Authors: Yan Huang, Nina Bucevic, Carmen Coves, Natalia Felipe-Medina, Marina Marcet-Ortega, Nikoleta Nikou, Cristina Madrid-Sandín, Maria López-Panadés, Carolina Buza, Neus Ferrer Miralles, Antoni Iborra, Anna Pujol, Alberto M Pendás, Ignasi Roig
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
gametogenesis
meiosis
BEND2
ovarian reserve
infertility
Online Access:https://elifesciences.org/articles/96052
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https://elifesciences.org/articles/96052

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