Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults
Abstract Background Declining gait performance is seen in aging individuals, due to neural and systemic factors. Plasma biomarkers provide an accessible way to assess evolving brain changes; non-specific neurodegeneration (NfL, GFAP) or evolving Alzheimer’s disease (Aβ 42/40 ratio, P-Tau181). Method...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-024-00713-6 |
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| author | Farwa Ali Jeremy A. Syrjanen Dan J. Figdore Walter K. Kremers Michelle M. Mielke Clifford R. Jack David S. Knopman Prashanthi Vemuri Jonathan Graff-Radford B. Gwen Windham Leland R. Barnard Ronald C. Petersen Alicia Algeciras-Schimnich |
| author_facet | Farwa Ali Jeremy A. Syrjanen Dan J. Figdore Walter K. Kremers Michelle M. Mielke Clifford R. Jack David S. Knopman Prashanthi Vemuri Jonathan Graff-Radford B. Gwen Windham Leland R. Barnard Ronald C. Petersen Alicia Algeciras-Schimnich |
| author_sort | Farwa Ali |
| collection | DOAJ |
| description | Abstract Background Declining gait performance is seen in aging individuals, due to neural and systemic factors. Plasma biomarkers provide an accessible way to assess evolving brain changes; non-specific neurodegeneration (NfL, GFAP) or evolving Alzheimer’s disease (Aβ 42/40 ratio, P-Tau181). Methods In a population-based cohort of older adults, we evaluate the hypothesis that plasma biomarkers of neurodegeneration and Alzheimer’s Disease pathology are associated with worse gait performance. A sample of 2641 Mayo Clinic Study of Aging participants with measurements of plasma biomarkers and gait parameters was analyzed in this cross-sectional study. Linear regression models using plasma biomarkers as predictors of gait parameters and adjusted for age, sex, BMI, Charlson Comorbidity Index, and cognitive diagnosis were evaluated. Results In this study multiple statistically significant relationships are observed for GFAP, NfL, and P-Tau181 with gait parameters. Each standard deviation increase in GFAP, NfL, and P-Tau181 is associated with a reduction in velocity of 2.100 (95% CI: −3.004, −1.196; p = 5.4 × 10−6), 4.400 (−5.292, -3.507; p = 9.5 × 10−22), and 2.617 (−3.414, −1.819; p = 1.5 × 10−10) cm/sec, respectively. Overall, NfL has the strongest associations with poor gait performance. Models with age interactions show that the strength of associations between the plasma biomarkers and the gait parameters became stronger with increasing age. There are no specific gait parameters that associate with individual plasma biomarkers. Conclusion Plasma biomarkers of neurodegeneration and Alzheimer’s Disease pathology are not only markers of cognitive decline but also indicate motor decline in the aging population. |
| format | Article |
| id | doaj-art-742a94ea042a4ba88f8435374b87cc27 |
| institution | Kabale University |
| issn | 2730-664X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj-art-742a94ea042a4ba88f8435374b87cc272025-01-19T12:36:56ZengNature PortfolioCommunications Medicine2730-664X2025-01-01511810.1038/s43856-024-00713-6Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adultsFarwa Ali0Jeremy A. Syrjanen1Dan J. Figdore2Walter K. Kremers3Michelle M. Mielke4Clifford R. Jack5David S. Knopman6Prashanthi Vemuri7Jonathan Graff-Radford8B. Gwen Windham9Leland R. Barnard10Ronald C. Petersen11Alicia Algeciras-Schimnich12Department of Neurology, Mayo ClinicDepartment of Quantitative Health Sciences, Mayo ClinicDepartment of Laboratory Medicine and Pathology, Mayo ClinicDepartment of Quantitative Health Sciences, Mayo ClinicDepartment of Epidemiology and Prevention, Wake Forest University School of MedicineDepartment of Radiology, Mayo ClinicDepartment of Neurology, Mayo ClinicDepartment of Radiology, Mayo ClinicDepartment of Neurology, Mayo ClinicDepartment of Medicine, The MIND Center, University of Mississippi Medical CenterDepartment of Neurology, Mayo ClinicDepartment of Neurology, Mayo ClinicDepartment of Laboratory Medicine and Pathology, Mayo ClinicAbstract Background Declining gait performance is seen in aging individuals, due to neural and systemic factors. Plasma biomarkers provide an accessible way to assess evolving brain changes; non-specific neurodegeneration (NfL, GFAP) or evolving Alzheimer’s disease (Aβ 42/40 ratio, P-Tau181). Methods In a population-based cohort of older adults, we evaluate the hypothesis that plasma biomarkers of neurodegeneration and Alzheimer’s Disease pathology are associated with worse gait performance. A sample of 2641 Mayo Clinic Study of Aging participants with measurements of plasma biomarkers and gait parameters was analyzed in this cross-sectional study. Linear regression models using plasma biomarkers as predictors of gait parameters and adjusted for age, sex, BMI, Charlson Comorbidity Index, and cognitive diagnosis were evaluated. Results In this study multiple statistically significant relationships are observed for GFAP, NfL, and P-Tau181 with gait parameters. Each standard deviation increase in GFAP, NfL, and P-Tau181 is associated with a reduction in velocity of 2.100 (95% CI: −3.004, −1.196; p = 5.4 × 10−6), 4.400 (−5.292, -3.507; p = 9.5 × 10−22), and 2.617 (−3.414, −1.819; p = 1.5 × 10−10) cm/sec, respectively. Overall, NfL has the strongest associations with poor gait performance. Models with age interactions show that the strength of associations between the plasma biomarkers and the gait parameters became stronger with increasing age. There are no specific gait parameters that associate with individual plasma biomarkers. Conclusion Plasma biomarkers of neurodegeneration and Alzheimer’s Disease pathology are not only markers of cognitive decline but also indicate motor decline in the aging population.https://doi.org/10.1038/s43856-024-00713-6 |
| spellingShingle | Farwa Ali Jeremy A. Syrjanen Dan J. Figdore Walter K. Kremers Michelle M. Mielke Clifford R. Jack David S. Knopman Prashanthi Vemuri Jonathan Graff-Radford B. Gwen Windham Leland R. Barnard Ronald C. Petersen Alicia Algeciras-Schimnich Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults Communications Medicine |
| title | Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults |
| title_full | Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults |
| title_fullStr | Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults |
| title_full_unstemmed | Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults |
| title_short | Association of plasma biomarkers of Alzheimer’s pathology and neurodegeneration with gait performance in older adults |
| title_sort | association of plasma biomarkers of alzheimer s pathology and neurodegeneration with gait performance in older adults |
| url | https://doi.org/10.1038/s43856-024-00713-6 |
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