DNA methylation-based profiling is an effective asset for identification of tumors in suspected, yet immunohistochemically, unspecified neuro-oncological cases

DNA methylation-based profiling is an effective asset for identification of tumors in suspected, yet immunohistochemically, unspecified neuro-oncological cases

Introduction: Patients with suspected neuro-oncological disease on radiographic images and no histopathological evidence of a tumor on the surgically retrieved tissue, pose a great challenge for clinicians and neuropathologists. Meanwhile, genome-wide DNA methylation-based molecular profiling has be...

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Bibliographic Details
Main Authors: Christian Uhl, Naseem Ayoub, Katharina Faust, Peter Vajkoczy, Leonille Schweizer, Josefine Radke, Felix Ehret, David Capper, Julia Sophie Onken
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Brain and Spine
Subjects:
Neuro-oncology
Neurosurgery
Genome-wide DNA methylation profiling
Copy number variation
Glioma
Histopathologically unspecifiable tissue
Online Access:http://www.sciencedirect.com/science/article/pii/S277252942500075X
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