Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.

Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.

<h4>Background</h4>An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB; Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known about the optimal treatment for these children.<h4>Methods and findings</h4>To inform t...

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Main Authors: Elizabeth P Harausz, Anthony J Garcia-Prats, Stephanie Law, H Simon Schaaf, Tamara Kredo, James A Seddon, Dick Menzies, Anna Turkova, Jay Achar, Farhana Amanullah, Pennan Barry, Mercedes Becerra, Edward D Chan, Pei Chun Chan, Domnica Ioana Chiotan, Aldo Crossa, Peter C Drobac, Lee Fairlie, Dennis Falzon, Jennifer Flood, Medea Gegia, Robert M Hicks, Petros Isaakidis, S M Kadri, Beate Kampmann, Shabir A Madhi, Else Marais, Andrei Mariandyshev, Ana Méndez-Echevarría, Brittany Kathryn Moore, Parpieva Nargiza, Iveta Ozere, Nesri Padayatchi, Saleem- Ur-Rehman, Natasha Rybak, Begoña Santiago-Garcia, N Sarita Shah, Sangeeta Sharma, Tae Sun Shim, Alena Skrahina, Antoni Soriano-Arandes, Martin van den Boom, Marieke J van der Werf, Tjip S van der Werf, Bhanu Williams, Elena Yablokova, Jae-Joon Yim, Jennifer Furin, Anneke C Hesseling, Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-07-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1002591
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https://doi.org/10.1371/journal.pmed.1002591

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