Combination of astragalus polysaccharide with Diosbulbin B exerts an enhanced antitumor effect in BRAF mut papillary thyroid cancer with decreased liver toxicity

Combination of astragalus polysaccharide with Diosbulbin B exerts an enhanced antitumor effect in BRAF mut papillary thyroid cancer with decreased liver toxicity

Abstract Background Diosbulbin B (DB) is a traditional Chinese medicine used for thyroid cancer treatment, but always brings severe liver injury. In the current study, we investigated the role of astragalus polysaccharide (APS) in DB-induced hepatotoxicity and their anti-tumor effect on BRAF mut pap...

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Bibliographic Details
Main Authors: Shuai Xu, Qi Liang, Hang Li, Hai Zhou, Zhenyuan Xu, Yanjun Yan, Yue Zhang, Renqun Ye, Xujun You
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
BRAF mut papillary thyroid cancer
Liver injury
Astragalus polysaccharide
Diosbulbin B
Ferroptosis
Online Access:https://doi.org/10.1186/s12935-025-03853-4
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https://doi.org/10.1186/s12935-025-03853-4

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