A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

Abstract The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing the highly amyloidogenic 49–127 trun...

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Main Authors: Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti
Format: Article
Language:English
Published: Springer Nature 2015-08-01
Series:EMBO Molecular Medicine
Subjects:
amyloid
mechano‐enzymatic cleavage
transthyretin
Online Access:https://doi.org/10.15252/emmm.201505357
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https://doi.org/10.15252/emmm.201505357

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