Hyperthermic intraperitoneal chemotherapy: Ideal and reality
Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) is a new adjuvant therapy for the treatment of abdominal malignant tumors and metastases, which has shown great potential. The HIPEC technique can effectively kill residual lesions in the abdominal cavity through the synergistic sensitization effec...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958424024886 |
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| author | Fan-He Dong Yu-Qiang Shan Wen-Cheng Kong Hao-Ran Wei Lin-Po Zhou Ye-Bin Yang Jing Shi Cheng-Hao Ji Yi-Jia Zhang |
| author_facet | Fan-He Dong Yu-Qiang Shan Wen-Cheng Kong Hao-Ran Wei Lin-Po Zhou Ye-Bin Yang Jing Shi Cheng-Hao Ji Yi-Jia Zhang |
| author_sort | Fan-He Dong |
| collection | DOAJ |
| description | Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) is a new adjuvant therapy for the treatment of abdominal malignant tumors and metastases, which has shown great potential. The HIPEC technique can effectively kill residual lesions in the abdominal cavity through the synergistic sensitization effect of thermal chemotherapy and the circulating perfusion and washing effect of large volume perfusion fluid, thereby reducing the occurrence of malignant ascites and reducing the risk of postoperative recurrence and metastasis. However, there are still many problems in the practical operation of HIPEC, such as non-uniform distribution of perfusate temperature, inadequate perfusion due to the presence of ‘dead space’, incomplete cytoreductive surgery (CRS), instances of catheter obstruction during perfusate circulation, the lack of a uniform standard for selecting appropriate HIPEC techniques, occupational exposure of medical personnel during the HIPEC procedure, and the selection of HIPEC chemotherapy regimens for patients with various types of tumors. This article aims to summarize the problems encountered in the clinical practice of HIPEC, explore the problems that can be improved, and put forward some suggestions, so as to promote the further standardization and normalization of HIPEC technology. |
| format | Article |
| id | doaj-art-7389cfd7ebfe4f7f8a55d86bdb2b3b66 |
| institution | Kabale University |
| issn | 1015-9584 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj-art-7389cfd7ebfe4f7f8a55d86bdb2b3b662025-01-30T05:13:44ZengElsevierAsian Journal of Surgery1015-95842025-02-01482986995Hyperthermic intraperitoneal chemotherapy: Ideal and realityFan-He Dong0Yu-Qiang Shan1Wen-Cheng Kong2Hao-Ran Wei3Lin-Po Zhou4Ye-Bin Yang5Jing Shi6Cheng-Hao Ji7Yi-Jia Zhang8Zhejiang Chinese Medical University, Hangzhou, ChinaAffiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Corresponding author.Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; Corresponding author.Zhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaZhejiang Chinese Medical University, Hangzhou, ChinaHyperthermic Intraperitoneal Chemoperfusion (HIPEC) is a new adjuvant therapy for the treatment of abdominal malignant tumors and metastases, which has shown great potential. The HIPEC technique can effectively kill residual lesions in the abdominal cavity through the synergistic sensitization effect of thermal chemotherapy and the circulating perfusion and washing effect of large volume perfusion fluid, thereby reducing the occurrence of malignant ascites and reducing the risk of postoperative recurrence and metastasis. However, there are still many problems in the practical operation of HIPEC, such as non-uniform distribution of perfusate temperature, inadequate perfusion due to the presence of ‘dead space’, incomplete cytoreductive surgery (CRS), instances of catheter obstruction during perfusate circulation, the lack of a uniform standard for selecting appropriate HIPEC techniques, occupational exposure of medical personnel during the HIPEC procedure, and the selection of HIPEC chemotherapy regimens for patients with various types of tumors. This article aims to summarize the problems encountered in the clinical practice of HIPEC, explore the problems that can be improved, and put forward some suggestions, so as to promote the further standardization and normalization of HIPEC technology.http://www.sciencedirect.com/science/article/pii/S1015958424024886HIPECProblemsSuggestionsStandardizationCRS |
| spellingShingle | Fan-He Dong Yu-Qiang Shan Wen-Cheng Kong Hao-Ran Wei Lin-Po Zhou Ye-Bin Yang Jing Shi Cheng-Hao Ji Yi-Jia Zhang Hyperthermic intraperitoneal chemotherapy: Ideal and reality Asian Journal of Surgery HIPEC Problems Suggestions Standardization CRS |
| title | Hyperthermic intraperitoneal chemotherapy: Ideal and reality |
| title_full | Hyperthermic intraperitoneal chemotherapy: Ideal and reality |
| title_fullStr | Hyperthermic intraperitoneal chemotherapy: Ideal and reality |
| title_full_unstemmed | Hyperthermic intraperitoneal chemotherapy: Ideal and reality |
| title_short | Hyperthermic intraperitoneal chemotherapy: Ideal and reality |
| title_sort | hyperthermic intraperitoneal chemotherapy ideal and reality |
| topic | HIPEC Problems Suggestions Standardization CRS |
| url | http://www.sciencedirect.com/science/article/pii/S1015958424024886 |
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