LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36

LIX1L aggravates MASH-HCC progression by reprogramming of hepatic metabolism and microenvironment via CD36

Limb expression 1-like protein (LIX1L) is an essential player in liver disorders, but its function in metabolic dysfunction-associated steatohepatitis (MASH) and associated hepatocellular carcinoma (HCC) progression remains obscure. Here, we identify LIX1L as a key integrative regulator linking lipi...

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Bibliographic Details
Main Authors: Yingrong Leng, Yanqiu Zhang, Yang Cheng, Shengtao Ye, Ying Zheng, Mengmeng He, Enyi Wu, Lingyi Kong, Hao Zhang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
MASLD
MASH
Hepatocellular carcinoma
Adipose expansion
PARylation
RNA decay
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824005127
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