Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model

Antiretroviral drug therapy does not reduce neuroinflammation in an HIV-1 infection brain organoid model

Abstract Background HIV-1-associated neurocognitive impairment (HIV-1-NCI) is marked by ongoing and chronic neuroinflammation with loss and decline in neuronal function even when antiretroviral drug therapy (ART) successfully suppresses viral replication. Microglia, the primary reservoirs of HIV-1 i...

Full description

Saved in:
Bibliographic Details
Main Authors: Samuel Martinez-Meza, Thomas A. Premeaux, Stefano M. Cirigliano, Courtney M. Friday, Stephanie Michael, Sonia Mediouni, Susana T. Valente, Lishomwa C. Ndhlovu, Howard A. Fine, Robert L. Furler O’Brien, Douglas F. Nixon
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Neuroinflammation
Subjects:
HIV-1
Neurocognitive
Brain
Organoid
Microglia
Neurons
Online Access:https://doi.org/10.1186/s12974-025-03375-w
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12974-025-03375-w

Similar Items