Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis
Background. Helicobacter pylori is detected in various extragastric diseases, including biliary tract cancers. Besides, gallbladder cancers, extracholangiocarcinomas, and intracholangiocarcinomas are highly lethal cancers with limited survival due to their late diagnosis. Epidemiological data on Hel...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2020/9287157 |
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| author | Soumia Cherif Kaoutar Bouriat Hanane Rais Said Elantri Abdessamad Amine |
| author_facet | Soumia Cherif Kaoutar Bouriat Hanane Rais Said Elantri Abdessamad Amine |
| author_sort | Soumia Cherif |
| collection | DOAJ |
| description | Background. Helicobacter pylori is detected in various extragastric diseases, including biliary tract cancers. Besides, gallbladder cancers, extracholangiocarcinomas, and intracholangiocarcinomas are highly lethal cancers with limited survival due to their late diagnosis. Epidemiological data on Helicobacter pylori infection and biliary tract cancer have been contradictory. Aim. The aim of this study is to explore and evaluate the association between the Helicobacter pylori infection and biliary tract cancer. Materials and Methods. Systematic literature research was carried out to identify all eligible articles. All relevant publications from 2000 to 2019 were retrieved using comprehensive combinations of keywords. We used a random effects model to calculate pooled prevalence estimates, and 95% confidence intervals (CIs) for odds ratio were also calculated. Quantitative assessment of heterogeneity was explored by the chi-square test and was measured using I2. Results. Thirteen case-control studies published between 2001 and 2018 were included. The overall meta-analysis favoured a significant association between Helicobacter pylori infection and biliary tract cancer (OR, 2.57; 95% CI, 1.35–4.91; I2 = 58%). Geographic distribution-based subgroup analysis showed a higher prevalence of H. pylori in Asian and North American countries. Evidence supporting the higher presence of Helicobacter pylori in a cancer group was found by PCR. In another subgroup, the ORs were 4.18 (2.03, 8.58) in cholangiocarcinoma, 1.36 (0.34, 5.44) in gallbladder cancer, and 5.93 (1.89, 18.63) in other biliary tract cancers. Conclusion. This meta-analysis suggests that infection of the biliary tract with Helicobacter pylori is related to an increased risk of biliary tract cancers. |
| format | Article |
| id | doaj-art-735ace6b4c9748b9ae122fc51d64a3a8 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-735ace6b4c9748b9ae122fc51d64a3a82025-02-03T01:04:19ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932020-01-01202010.1155/2020/92871579287157Helicobacter pylori and Biliary Tract Cancers: A Meta-AnalysisSoumia Cherif0Kaoutar Bouriat1Hanane Rais2Said Elantri3Abdessamad Amine4Laboratory of Biochemistry, Environment, and Agrifood, Faculty of Sciences and Techniques-Mohammedia, Hassan II University, Casablanca, MoroccoLaboratory of Biochemistry, Environment, and Agrifood, Faculty of Sciences and Techniques-Mohammedia, Hassan II University, Casablanca, MoroccoDepartment of Pathology, ARRAZI Hospital, Biopathology Laboratory-Clinical Research Center, Mohammed VI University Hospital, Marrakech, MoroccoLaboratory of Biochemistry, Environment, and Agrifood, Faculty of Sciences and Techniques-Mohammedia, Hassan II University, Casablanca, MoroccoDepartment of Pathology, ARRAZI Hospital, Biopathology Laboratory-Clinical Research Center, Mohammed VI University Hospital, Marrakech, MoroccoBackground. Helicobacter pylori is detected in various extragastric diseases, including biliary tract cancers. Besides, gallbladder cancers, extracholangiocarcinomas, and intracholangiocarcinomas are highly lethal cancers with limited survival due to their late diagnosis. Epidemiological data on Helicobacter pylori infection and biliary tract cancer have been contradictory. Aim. The aim of this study is to explore and evaluate the association between the Helicobacter pylori infection and biliary tract cancer. Materials and Methods. Systematic literature research was carried out to identify all eligible articles. All relevant publications from 2000 to 2019 were retrieved using comprehensive combinations of keywords. We used a random effects model to calculate pooled prevalence estimates, and 95% confidence intervals (CIs) for odds ratio were also calculated. Quantitative assessment of heterogeneity was explored by the chi-square test and was measured using I2. Results. Thirteen case-control studies published between 2001 and 2018 were included. The overall meta-analysis favoured a significant association between Helicobacter pylori infection and biliary tract cancer (OR, 2.57; 95% CI, 1.35–4.91; I2 = 58%). Geographic distribution-based subgroup analysis showed a higher prevalence of H. pylori in Asian and North American countries. Evidence supporting the higher presence of Helicobacter pylori in a cancer group was found by PCR. In another subgroup, the ORs were 4.18 (2.03, 8.58) in cholangiocarcinoma, 1.36 (0.34, 5.44) in gallbladder cancer, and 5.93 (1.89, 18.63) in other biliary tract cancers. Conclusion. This meta-analysis suggests that infection of the biliary tract with Helicobacter pylori is related to an increased risk of biliary tract cancers.http://dx.doi.org/10.1155/2020/9287157 |
| spellingShingle | Soumia Cherif Kaoutar Bouriat Hanane Rais Said Elantri Abdessamad Amine Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis |
| title_full | Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis |
| title_fullStr | Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis |
| title_full_unstemmed | Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis |
| title_short | Helicobacter pylori and Biliary Tract Cancers: A Meta-Analysis |
| title_sort | helicobacter pylori and biliary tract cancers a meta analysis |
| url | http://dx.doi.org/10.1155/2020/9287157 |
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