Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved]
Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. This study aimed to assess whether changes of skeletal muscle mass (SMM) over time are...
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Wellcome
2025-01-01
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| Online Access: | https://wellcomeopenresearch.org/articles/9-565/v4 |
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| author | Enrique S. Nuñez-del-Arco Renzo A. Agurto-García Rodrigo M. Carrillo-Larco J. Jaime Miranda Antonio Bernabe-Ortiz |
| author_facet | Enrique S. Nuñez-del-Arco Renzo A. Agurto-García Rodrigo M. Carrillo-Larco J. Jaime Miranda Antonio Bernabe-Ortiz |
| author_sort | Enrique S. Nuñez-del-Arco |
| collection | DOAJ |
| description | Background The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. This study aimed to assess whether changes of skeletal muscle mass (SMM) over time are associated with baseline sleep duration and disturbances in a resource-constrained adult Peruvian population. Materials and Methods Secondary analysis using information of a population-based intervention. The outcome was SMM assessed using bioimpedance and the second version of the Lee’s formula. The exposures were baseline self-reported sleep duration (normal, short and long sleepers) and disturbances (sleep difficulties and awakening at nights). Crude and adjusted linear mixed models were used to assess the associations of interest, and coefficients (β) and 95% confidence intervales (95% CI) were reported. Results Data from 2,310 individuals at baseline, mean age 43.4 (SD: 17.2), and 1,163 (50.4%) females were analyzed. Sleep duration was 7.8 (SD: 1.3) hours/day, with 15.3% short sleepers and 11.6% long sleepers, whereas 24.2% reported sleep difficulties and 25.1% awakening at nights. In multivariable model, SMM among short and long sleepers did not vary significantly over time using the Lee’s formula; however, SMM was lower at the end of follow-up for long sleepers using bioimpedance (-0.26 kg; 95% CI: -0.47 to -0.06). Sleep disturbances were associated with a gradual SMM reduction: 0.36 kg using bioimpedance and 0.25 kg using the formula at the end of follow-up. Conclusions Using bioimpedance and formula estimations, sleep disturbances were associated with a reduction of SMM over a period of 2.4 years. Regarding sleep duration, no SMM changes over time were seen in short sleepers, but findings were discordant in long sleepers: a reduction of SMM using bioimpedance, but no change using the formula. |
| format | Article |
| id | doaj-art-7312d68db68e4ef2aac932e22e998768 |
| institution | Kabale University |
| issn | 2398-502X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wellcome |
| record_format | Article |
| series | Wellcome Open Research |
| spelling | doaj-art-7312d68db68e4ef2aac932e22e9987682025-01-29T01:00:01ZengWellcomeWellcome Open Research2398-502X2025-01-01926123Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved]Enrique S. Nuñez-del-Arco0https://orcid.org/0000-0002-4820-6847Renzo A. Agurto-García1Rodrigo M. Carrillo-Larco2J. Jaime Miranda3https://orcid.org/0000-0002-4738-5468Antonio Bernabe-Ortiz4https://orcid.org/0000-0002-6834-1376Universidad Cientifica del Sur, Lima, PeruUniversidad Cientifica del Sur, Lima, PeruEmory University Hubert Department of Global Health, Atlanta, Georgia, USACRONICAS Center of Excellence in Chronic Diseases, Universidad Peruana Cayetano Heredia, Lima, PeruUniversidad Cientifica del Sur, Lima, PeruBackground The skeletal muscle has mainly a structural function and plays a role in human’s metabolism. Besides, the association between sleep quality and muscle mass, in the form of sarcopenia, has been reported. This study aimed to assess whether changes of skeletal muscle mass (SMM) over time are associated with baseline sleep duration and disturbances in a resource-constrained adult Peruvian population. Materials and Methods Secondary analysis using information of a population-based intervention. The outcome was SMM assessed using bioimpedance and the second version of the Lee’s formula. The exposures were baseline self-reported sleep duration (normal, short and long sleepers) and disturbances (sleep difficulties and awakening at nights). Crude and adjusted linear mixed models were used to assess the associations of interest, and coefficients (β) and 95% confidence intervales (95% CI) were reported. Results Data from 2,310 individuals at baseline, mean age 43.4 (SD: 17.2), and 1,163 (50.4%) females were analyzed. Sleep duration was 7.8 (SD: 1.3) hours/day, with 15.3% short sleepers and 11.6% long sleepers, whereas 24.2% reported sleep difficulties and 25.1% awakening at nights. In multivariable model, SMM among short and long sleepers did not vary significantly over time using the Lee’s formula; however, SMM was lower at the end of follow-up for long sleepers using bioimpedance (-0.26 kg; 95% CI: -0.47 to -0.06). Sleep disturbances were associated with a gradual SMM reduction: 0.36 kg using bioimpedance and 0.25 kg using the formula at the end of follow-up. Conclusions Using bioimpedance and formula estimations, sleep disturbances were associated with a reduction of SMM over a period of 2.4 years. Regarding sleep duration, no SMM changes over time were seen in short sleepers, but findings were discordant in long sleepers: a reduction of SMM using bioimpedance, but no change using the formula.https://wellcomeopenresearch.org/articles/9-565/v4Skeletal muscle sleep duration sleep hygiene sleep disturbances.eng |
| spellingShingle | Enrique S. Nuñez-del-Arco Renzo A. Agurto-García Rodrigo M. Carrillo-Larco J. Jaime Miranda Antonio Bernabe-Ortiz Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved] Wellcome Open Research Skeletal muscle sleep duration sleep hygiene sleep disturbances. eng |
| title | Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_full | Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_fullStr | Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_full_unstemmed | Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_short | Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with reservations, 1 not approved] |
| title_sort | sleep duration sleep disturbances and skeletal muscle mass change over time a population based longitudinal analysis in peru version 4 peer review 1 approved 2 approved with reservations 1 not approved |
| topic | Skeletal muscle sleep duration sleep hygiene sleep disturbances. eng |
| url | https://wellcomeopenresearch.org/articles/9-565/v4 |
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