Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases
Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metasta...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/690548 |
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| author | Nathan C. Rowland Jennifer Andrews Daxa Patel David V. LaBorde Adam Nowlan Bradley George Claire Mazewski Andrew Reisner Howard M. Katzenstein |
| author_facet | Nathan C. Rowland Jennifer Andrews Daxa Patel David V. LaBorde Adam Nowlan Bradley George Claire Mazewski Andrew Reisner Howard M. Katzenstein |
| author_sort | Nathan C. Rowland |
| collection | DOAJ |
| description | Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease. |
| format | Article |
| id | doaj-art-7302e2a2c0ea4c5ba3bcb7a68d664139 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-7302e2a2c0ea4c5ba3bcb7a68d6641392025-02-03T01:26:30ZengWileyCase Reports in Neurological Medicine2090-66682090-66762012-01-01201210.1155/2012/690548690548Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel CasesNathan C. Rowland0Jennifer Andrews1Daxa Patel2David V. LaBorde3Adam Nowlan4Bradley George5Claire Mazewski6Andrew Reisner7Howard M. Katzenstein8Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room 779 M, San Francisco, CA 94143-0112, USAAflac Cancer Center, Department of Pediatrics, Children's Healthcare of Atlanta, 1405 Clifton Road NE, Third Floor, Atlanta, GA 30322, USADivision of Neurolosurgery, University of Alabama at Birmingham, 510 Twentieth Street South, 1060 Faculty Office Tower, Birmingham, AL 35294-3410, USADepartment of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road NE, Building B, Suite 2200, Atlanta, GA 30322, USADepartment of Radiation Oncology, Piedmont Hospital, 1968 Peachtree Road NW, Atlanta, GA 30309, USAAflac Cancer Center, Department of Pediatrics, Children's Healthcare of Atlanta, 1405 Clifton Road NE, Third Floor, Atlanta, GA 30322, USAAflac Cancer Center, Department of Pediatrics, Children's Healthcare of Atlanta, 1405 Clifton Road NE, Third Floor, Atlanta, GA 30322, USADepartment of Neurosurgery, Emory University School of Medicine, 1365 Clifton Road NE, Building B, Suite 2200, Atlanta, GA 30322, USAAflac Cancer Center, Department of Pediatrics, Children's Healthcare of Atlanta, 1405 Clifton Road NE, Third Floor, Atlanta, GA 30322, USAIntracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.http://dx.doi.org/10.1155/2012/690548 |
| spellingShingle | Nathan C. Rowland Jennifer Andrews Daxa Patel David V. LaBorde Adam Nowlan Bradley George Claire Mazewski Andrew Reisner Howard M. Katzenstein Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases Case Reports in Neurological Medicine |
| title | Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases |
| title_full | Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases |
| title_fullStr | Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases |
| title_full_unstemmed | Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases |
| title_short | Intracranial Metastatic Neuroblastoma Treated with Gamma Knife Stereotactic Radiosurgery: Report of Two Novel Cases |
| title_sort | intracranial metastatic neuroblastoma treated with gamma knife stereotactic radiosurgery report of two novel cases |
| url | http://dx.doi.org/10.1155/2012/690548 |
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