Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview
Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/476068 |
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| _version_ | 1832566545293770752 |
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| author | Jaroslav Mysak Stepan Podzimek Pavla Sommerova Yelena Lyuya-Mi Jirina Bartova Tatjana Janatova Jarmila Prochazkova Jana Duskova |
| author_facet | Jaroslav Mysak Stepan Podzimek Pavla Sommerova Yelena Lyuya-Mi Jirina Bartova Tatjana Janatova Jarmila Prochazkova Jana Duskova |
| author_sort | Jaroslav Mysak |
| collection | DOAJ |
| description | Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens—Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the “red complex,” a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity. |
| format | Article |
| id | doaj-art-72bf9efd10824c9ca29101b37a4ddb03 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-72bf9efd10824c9ca29101b37a4ddb032025-02-03T01:03:45ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/476068476068Porphyromonas gingivalis: Major Periodontopathic Pathogen OverviewJaroslav Mysak0Stepan Podzimek1Pavla Sommerova2Yelena Lyuya-Mi3Jirina Bartova4Tatjana Janatova5Jarmila Prochazkova6Jana Duskova7Institute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicInstitute of Clinical and Experimental Dental Medicine, First Faculty of Medicine and General University Hospital, Charles University, Karlovo Namesti 32, 12000 Prague, Czech RepublicPorphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens—Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the “red complex,” a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.http://dx.doi.org/10.1155/2014/476068 |
| spellingShingle | Jaroslav Mysak Stepan Podzimek Pavla Sommerova Yelena Lyuya-Mi Jirina Bartova Tatjana Janatova Jarmila Prochazkova Jana Duskova Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview Journal of Immunology Research |
| title | Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview |
| title_full | Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview |
| title_fullStr | Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview |
| title_full_unstemmed | Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview |
| title_short | Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview |
| title_sort | porphyromonas gingivalis major periodontopathic pathogen overview |
| url | http://dx.doi.org/10.1155/2014/476068 |
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