Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma
Abstract Objective: The average age of patients with vulvar squamous cell carcinoma (SCC) has been reported to have declined. Human papilloma virus (HPV)-related lesions have been shown to be associated with the expression of the immunohistochemical (IHC) marker p16. Non-HPV-related tumors have bee...
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2025-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100263&lng=en&tlng=en |
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| _version_ | 1832592573133225984 |
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| author | Lorenza Bridi Todeschini Rita de Cássia Sant’Anna Alves Adriana Vial Roehe |
| author_facet | Lorenza Bridi Todeschini Rita de Cássia Sant’Anna Alves Adriana Vial Roehe |
| author_sort | Lorenza Bridi Todeschini |
| collection | DOAJ |
| description | Abstract Objective: The average age of patients with vulvar squamous cell carcinoma (SCC) has been reported to have declined. Human papilloma virus (HPV)-related lesions have been shown to be associated with the expression of the immunohistochemical (IHC) marker p16. Non-HPV-related tumors have been characterized by p53 abnormal expression and PDL1 expression. We aimed to evaluate the correlation between these markers and vulvar SCC and to relate it to the clinical and pathological characteristics. Methods: Histopathologic assessments and IHC analyses of p16, p53, and PDL1 were performed in 41 samples of vulvar SCC collected between 2016 and 2021. The data were correlated with clinical and pathological characteristics of the patients. Results: The mean age of the patients was 72.1 years. Positive p16 and PDL1 staining was detected in 24.4% and 17.1% of the samples, respectively. p53 expression was negative in 19.5% of the samples, whereas it was overexpressed in 24.4%. p16-positive tumors showed a smaller depth of invasion (DOI) (p = 0.014), while tumors with p53 abnormal expression showed greater DOI (p = 0.041). PDL1 expression was correlated with increased number of inflammatory cells (p = 0.055). In addition, lesions with lymphovascular space invasion were p16-negative. Conclusion: In our sample, regarding to the SCC incidence the patients’ mean age did not change. The expression of p16 was inversely correlated with p53 results. Tumors with p53 abnormal expression and absence of p16 showed a greater DOI. Our data suggest an association between PDL1 expression and increased inflammatory infiltrates in vulvar SCC. |
| format | Article |
| id | doaj-art-72b881cb9c3f43bc8d1c76ddcc38e035 |
| institution | Kabale University |
| issn | 0100-7203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj-art-72b881cb9c3f43bc8d1c76ddcc38e0352025-01-21T07:35:53ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032025-01-014610.61622/rbgo/2024rbgo91Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinomaLorenza Bridi Todeschinihttps://orcid.org/0000-0002-9593-912XRita de Cássia Sant’Anna Alveshttps://orcid.org/0000-0003-1204-4978Adriana Vial Roehehttps://orcid.org/0000-0002-6294-7342Abstract Objective: The average age of patients with vulvar squamous cell carcinoma (SCC) has been reported to have declined. Human papilloma virus (HPV)-related lesions have been shown to be associated with the expression of the immunohistochemical (IHC) marker p16. Non-HPV-related tumors have been characterized by p53 abnormal expression and PDL1 expression. We aimed to evaluate the correlation between these markers and vulvar SCC and to relate it to the clinical and pathological characteristics. Methods: Histopathologic assessments and IHC analyses of p16, p53, and PDL1 were performed in 41 samples of vulvar SCC collected between 2016 and 2021. The data were correlated with clinical and pathological characteristics of the patients. Results: The mean age of the patients was 72.1 years. Positive p16 and PDL1 staining was detected in 24.4% and 17.1% of the samples, respectively. p53 expression was negative in 19.5% of the samples, whereas it was overexpressed in 24.4%. p16-positive tumors showed a smaller depth of invasion (DOI) (p = 0.014), while tumors with p53 abnormal expression showed greater DOI (p = 0.041). PDL1 expression was correlated with increased number of inflammatory cells (p = 0.055). In addition, lesions with lymphovascular space invasion were p16-negative. Conclusion: In our sample, regarding to the SCC incidence the patients’ mean age did not change. The expression of p16 was inversely correlated with p53 results. Tumors with p53 abnormal expression and absence of p16 showed a greater DOI. Our data suggest an association between PDL1 expression and increased inflammatory infiltrates in vulvar SCC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100263&lng=en&tlng=enVulvar squamous cell carcinomaImmunohistochemistryp16p53PDL1 |
| spellingShingle | Lorenza Bridi Todeschini Rita de Cássia Sant’Anna Alves Adriana Vial Roehe Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma Revista Brasileira de Ginecologia e Obstetrícia Vulvar squamous cell carcinoma Immunohistochemistry p16 p53 PDL1 |
| title | Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma |
| title_full | Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma |
| title_fullStr | Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma |
| title_full_unstemmed | Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma |
| title_short | Clinical, histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma |
| title_sort | clinical histopathological and immunohistochemical analysis of vulvar squamous cell carcinoma |
| topic | Vulvar squamous cell carcinoma Immunohistochemistry p16 p53 PDL1 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032024000100263&lng=en&tlng=en |
| work_keys_str_mv | AT lorenzabriditodeschini clinicalhistopathologicalandimmunohistochemicalanalysisofvulvarsquamouscellcarcinoma AT ritadecassiasantannaalves clinicalhistopathologicalandimmunohistochemicalanalysisofvulvarsquamouscellcarcinoma AT adrianavialroehe clinicalhistopathologicalandimmunohistochemicalanalysisofvulvarsquamouscellcarcinoma |