Pupil size modulation drives retinal activity in mice and shapes human perception

Pupil size modulation drives retinal activity in mice and shapes human perception

Abstract Retinal adaptation is assisted by the pupil, with pupil contraction and dilation thought to prevent global light changes from triggering neuronal activity in the retina. However, we find that pupillary constriction from increased light, the pupillary light reflex (PLR), can drive strong res...

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Main Authors: Tjasa Lapanja, Pietro Micheli, Andrés González-Guerra, Oleksandr Radomskyi, Gioia De Franceschi, Anna Muraveva, Alexander Attinger, Chiara Nina Roth, Matteo Tripodi, Tom Boissonnet, Marina Sabbadini, Josephine Jüttner, Petri Ala-Laurila, Georg Keller, Gabriel Peinado Allina, Hiroki Asari, Santiago B. Rompani
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62736-4
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https://doi.org/10.1038/s41467-025-62736-4

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