Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies
T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has al...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/2386187 |
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| _version_ | 1832549102204747776 |
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| author | Shangjun Sun He Hao Ge Yang Yi Zhang Yang Fu |
| author_facet | Shangjun Sun He Hao Ge Yang Yi Zhang Yang Fu |
| author_sort | Shangjun Sun |
| collection | DOAJ |
| description | T cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies. |
| format | Article |
| id | doaj-art-725b796a44ec40d6871c5bb81661c032 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-725b796a44ec40d6871c5bb81661c0322025-02-03T06:12:08ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/23861872386187Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming StrategiesShangjun Sun0He Hao1Ge Yang2Yi Zhang3Yang Fu4Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, ChinaBiotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, ChinaDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, ChinaT cells modified via chimeric antigen receptors (CARs) have emerged as a promising treatment modality. Unparalleled clinical efficacy recently demonstrated in refractory B-cell malignancy has brought this new form of adoptive immunotherapy to the center stage. Nonetheless, its current success has also highlighted its potential treatment-related toxicities. The adverse events observed in the clinical trials are described in this review, after which, some innovative strategies developed to overcome these unwanted toxicities are outlined, including suicide genes, targeted activation, and other novel strategies.http://dx.doi.org/10.1155/2018/2386187 |
| spellingShingle | Shangjun Sun He Hao Ge Yang Yi Zhang Yang Fu Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies Journal of Immunology Research |
| title | Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies |
| title_full | Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies |
| title_fullStr | Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies |
| title_full_unstemmed | Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies |
| title_short | Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies |
| title_sort | immunotherapy with car modified t cells toxicities and overcoming strategies |
| url | http://dx.doi.org/10.1155/2018/2386187 |
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