Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats
We studied the ability of Kalsis, a food supplement that contains selenium, citric acid, and vitamin E, to prevent the effects of ovariectomy on bone loss. Six-month-old, Wistar female rats were studied. Groups (n=12): SHAM: sham-operated rats; OVX: ovariectomized rats, treated with vehicle; OVX + K...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2012/639427 |
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| author | Mercedes Montero Manuel Díaz-Curiel David Guede Jose Ramón Caeiro Marta Martín-Fernández Mercedes Rubert Daisy Navarro Concepción de la Piedra |
| author_facet | Mercedes Montero Manuel Díaz-Curiel David Guede Jose Ramón Caeiro Marta Martín-Fernández Mercedes Rubert Daisy Navarro Concepción de la Piedra |
| author_sort | Mercedes Montero |
| collection | DOAJ |
| description | We studied the ability of Kalsis, a food supplement that contains selenium, citric acid, and vitamin E, to prevent the effects of ovariectomy on bone loss. Six-month-old, Wistar female rats were studied. Groups (n=12): SHAM: sham-operated rats; OVX: ovariectomized rats, treated with vehicle; OVX + Kalsis: ovariectomized rats treated with Kalsis (25 mg/kg/day) for 3 months. Bone mineral density (BMD) was determined by DXA in lumbar spine and femur. Computerized microtomography (μCT) in femur and serum osteocalcin (BGP), aminoterminal propeptide of procollagen I (PINP), β-isomer of carboxyterminal telopeptide of collagen I (CTX), and 5b isoenzyme of tartrate-resistant acid phosphatase (TRAP) were performed. Treatment with Kalsis prevented BMD loss in OVX group. μCT showed a decrease in BV/TV, and trabecular number, and an increase in trabecular separation in OVX rats. Kalsis administration attenuated partially bone loss observed by μCT due to ovariectomy. BGP, PINP, and the resorption index (CTX/TRAP) were increased in OVX group. Treatment with Kalsis maintained this increase. The mechanism of action of this supplement is not through a decrease in bone remodelling rate. The antioxidant action of this food supplement, due to the synergism of all its components, as a cause of its beneficial effect is suggested. |
| format | Article |
| id | doaj-art-7232726e9b264e81a73ac6fb95bbe092 |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-7232726e9b264e81a73ac6fb95bbe0922025-02-03T06:11:30ZengWileyJournal of Osteoporosis2090-80592042-00642012-01-01201210.1155/2012/639427639427Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized RatsMercedes Montero0Manuel Díaz-Curiel1David Guede2Jose Ramón Caeiro3Marta Martín-Fernández4Mercedes Rubert5Daisy Navarro6Concepción de la Piedra7Bioquímica Investigación, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, SpainInternal Medicine, Instituto de Investigación, Sanitaria Fundación Jiménez Díaz, 28040 Madrid, SpainTrabeculae Technology Based Firm, Technological Park of Galicia, 32900 Ourense, SpainTraumatology and Orthopedic Surgery, University Hospital Complex of Santiago de Compostela, 15706 Santiago de Compostela, SpainBioquímica Investigación, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, SpainBioquímica Investigación, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, SpainInstituto Nacional de Endocrinología, 10400 La Habana, CubaBioquímica Investigación, Instituto de Investigación Sanitaria, Fundación Jiménez Díaz, Avenida Reyes Católicos 2, 28040 Madrid, SpainWe studied the ability of Kalsis, a food supplement that contains selenium, citric acid, and vitamin E, to prevent the effects of ovariectomy on bone loss. Six-month-old, Wistar female rats were studied. Groups (n=12): SHAM: sham-operated rats; OVX: ovariectomized rats, treated with vehicle; OVX + Kalsis: ovariectomized rats treated with Kalsis (25 mg/kg/day) for 3 months. Bone mineral density (BMD) was determined by DXA in lumbar spine and femur. Computerized microtomography (μCT) in femur and serum osteocalcin (BGP), aminoterminal propeptide of procollagen I (PINP), β-isomer of carboxyterminal telopeptide of collagen I (CTX), and 5b isoenzyme of tartrate-resistant acid phosphatase (TRAP) were performed. Treatment with Kalsis prevented BMD loss in OVX group. μCT showed a decrease in BV/TV, and trabecular number, and an increase in trabecular separation in OVX rats. Kalsis administration attenuated partially bone loss observed by μCT due to ovariectomy. BGP, PINP, and the resorption index (CTX/TRAP) were increased in OVX group. Treatment with Kalsis maintained this increase. The mechanism of action of this supplement is not through a decrease in bone remodelling rate. The antioxidant action of this food supplement, due to the synergism of all its components, as a cause of its beneficial effect is suggested.http://dx.doi.org/10.1155/2012/639427 |
| spellingShingle | Mercedes Montero Manuel Díaz-Curiel David Guede Jose Ramón Caeiro Marta Martín-Fernández Mercedes Rubert Daisy Navarro Concepción de la Piedra Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats Journal of Osteoporosis |
| title | Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats |
| title_full | Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats |
| title_fullStr | Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats |
| title_full_unstemmed | Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats |
| title_short | Effects of Kalsis, A Dietary Supplement, on Bone Metabolism in the Ovariectomized Rats |
| title_sort | effects of kalsis a dietary supplement on bone metabolism in the ovariectomized rats |
| url | http://dx.doi.org/10.1155/2012/639427 |
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