CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription

CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription

Abstract The RNA helicase DDX41 is a DEAD-box helicase that is well known as a virus sensor in dendritic cells and a tumor suppressor that is frequently mutated in myeloid neoplasms. However, the functions and relevance of DDX41 in solid tumors remain largely unexplored. In this study, through in vi...

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Main Authors: Hongquan Li, Yifei He, Jiawen Jiang, Zhen Liu, Yizhe Liu, Qili Shi, Jie Ding, Haochen Li, Weili Sun, Xin Hu, Zhiao Chen, Xianghuo He
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62743-5
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https://doi.org/10.1038/s41467-025-62743-5

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