FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis

FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis

Abstract Background Acute pancreatitis (AP) presents a significant clinical challenge with limited therapeutic options. The complex etiology and pathophysiology of AP emphasize the need for innovative treatments. This study explores mRNA-based therapies delivering fibroblast growth factor 21 (FGF21)...

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Main Authors:	Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Series:	Journal of Translational Medicine
Subjects:	Acute pancreatitis mRNA therapy FGF21 APOA1 Cytoprotection Pancreatic injury
Online Access:	https://doi.org/10.1186/s12967-025-06129-7
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