Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival
Introduction. Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is characterized by extensive heterogeneity in its clinicopathological presentation. A primary brain tumor with both astrocytic differentiation and neuronal immunophenotype features is rare. Here, w...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2018/1382680 |
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| author | Ying-Tso Chen Shu-Shong Hsu Chi-Man Yip Ping-Hong Lai Huai-Pao Lee |
| author_facet | Ying-Tso Chen Shu-Shong Hsu Chi-Man Yip Ping-Hong Lai Huai-Pao Lee |
| author_sort | Ying-Tso Chen |
| collection | DOAJ |
| description | Introduction. Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is characterized by extensive heterogeneity in its clinicopathological presentation. A primary brain tumor with both astrocytic differentiation and neuronal immunophenotype features is rare. Here, we report a long-term survival patient who presented this rare form of GBM in the disease course. Presentation of Case. A 23-year-old woman, presenting with rapidly progressive headache and right-side weakness, was diagnosed with brain tumor over the left basal ganglion. She underwent the first craniectomy for tumor removal, and histopathology revealed classic GBM. Tumor recurrence occurred 8 years later. Another gross total resection was performed and pathology revealed GBM with the oligodendroglioma component (GBM-O). Due to disease progression, she received debulking surgery the following year. The third pathology revealed glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET). Discussion. GBM-PNETs are collision tumors with both neuronal and glial components. They are rare, and a few case reports have suggested that these tumors are associated with favorable outcomes but a higher risk of cerebrospinal fluid dissemination. Conclusion. We report a patient who developed the distinct pathologic variants of classic GBM, GBM-O, and GBM-PNET, throughout the disease course. Young age, aggressive surgical resection, and pathologic and genetic features may have contributed to the long-term survival of the patient. |
| format | Article |
| id | doaj-art-71a6b9d09f8d4832ab896edf5efd540a |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-71a6b9d09f8d4832ab896edf5efd540a2025-02-03T05:59:25ZengWileyCase Reports in Surgery2090-69002090-69192018-01-01201810.1155/2018/13826801382680Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year SurvivalYing-Tso Chen0Shu-Shong Hsu1Chi-Man Yip2Ping-Hong Lai3Huai-Pao Lee4Division of Neurosurgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDivision of Neurosurgery, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanDepartment of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung, TaiwanIntroduction. Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is characterized by extensive heterogeneity in its clinicopathological presentation. A primary brain tumor with both astrocytic differentiation and neuronal immunophenotype features is rare. Here, we report a long-term survival patient who presented this rare form of GBM in the disease course. Presentation of Case. A 23-year-old woman, presenting with rapidly progressive headache and right-side weakness, was diagnosed with brain tumor over the left basal ganglion. She underwent the first craniectomy for tumor removal, and histopathology revealed classic GBM. Tumor recurrence occurred 8 years later. Another gross total resection was performed and pathology revealed GBM with the oligodendroglioma component (GBM-O). Due to disease progression, she received debulking surgery the following year. The third pathology revealed glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET). Discussion. GBM-PNETs are collision tumors with both neuronal and glial components. They are rare, and a few case reports have suggested that these tumors are associated with favorable outcomes but a higher risk of cerebrospinal fluid dissemination. Conclusion. We report a patient who developed the distinct pathologic variants of classic GBM, GBM-O, and GBM-PNET, throughout the disease course. Young age, aggressive surgical resection, and pathologic and genetic features may have contributed to the long-term survival of the patient.http://dx.doi.org/10.1155/2018/1382680 |
| spellingShingle | Ying-Tso Chen Shu-Shong Hsu Chi-Man Yip Ping-Hong Lai Huai-Pao Lee Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival Case Reports in Surgery |
| title | Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival |
| title_full | Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival |
| title_fullStr | Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival |
| title_full_unstemmed | Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival |
| title_short | Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival |
| title_sort | glioblastoma with both oligodendroglioma and primitive neuroectodermal tumor like components in a case with 9 year survival |
| url | http://dx.doi.org/10.1155/2018/1382680 |
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