Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex
Abstract The retrosplenial cortex (RSP) is a complex brain region with multiple interconnected subregions that plays crucial roles in various cognitive functions, including memory, spatial navigation, and emotion. Understanding the afferent and efferent connectivity of the RSP is essential for compr...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07463-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594485616312320 |
|---|---|
| author | Yuxiao Li Miao Ren Bimin Liu Tao Jiang Xueyan Jia Haili Zhang Hui Gong Xiaojun Wang |
| author_facet | Yuxiao Li Miao Ren Bimin Liu Tao Jiang Xueyan Jia Haili Zhang Hui Gong Xiaojun Wang |
| author_sort | Yuxiao Li |
| collection | DOAJ |
| description | Abstract The retrosplenial cortex (RSP) is a complex brain region with multiple interconnected subregions that plays crucial roles in various cognitive functions, including memory, spatial navigation, and emotion. Understanding the afferent and efferent connectivity of the RSP is essential for comprehending the underlying mechanisms of its functions. Here, via viral tracing and fluorescence micro-optical sectioning tomography (fMOST), we systematically investigated the anatomical organisation of the upstream and downstream circuits of glutamatergic and GABAergic neurons in the dorsal and ventral RSP. The cortical connections of the RSP show laminar organisation in which the input neurons are distributed more in the deeper layers of the upstream cortex. Although different types of neurons have similar upstream circuits, GABAergic neurons show bidirectional connections with the hippocampus, whereas glutamatergic neurons only show unidirectional connections. Moreover, GABAergic neurons receive more inputs from the primary sensory cortex than from the prefrontal cortex and association cortex. The dorsal and ventral subregions have preferred circuits such that the dorsal RSP exhibits spatially topological connections with the dorsal visual cortex and lateral thalamus. The systematic study on long-range connections across RSP subregions and cell types may provide useful information for future revealing of RSP working mechanisms. |
| format | Article |
| id | doaj-art-7181be5a1b78455cb9d7be009615cbf6 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-7181be5a1b78455cb9d7be009615cbf62025-01-19T12:35:24ZengNature PortfolioCommunications Biology2399-36422025-01-018111410.1038/s42003-025-07463-8Dissection of the long-range circuit of the mouse intermediate retrosplenial cortexYuxiao Li0Miao Ren1Bimin Liu2Tao Jiang3Xueyan Jia4Haili Zhang5Hui Gong6Xiaojun Wang7Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan UniversityKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan UniversityKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan UniversityHUST-Suzhou Institute for Brainsmatics, JITRIHUST-Suzhou Institute for Brainsmatics, JITRISchool of Breeding and Multiplication, Hainan UniversityHUST-Suzhou Institute for Brainsmatics, JITRIKey Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan UniversityAbstract The retrosplenial cortex (RSP) is a complex brain region with multiple interconnected subregions that plays crucial roles in various cognitive functions, including memory, spatial navigation, and emotion. Understanding the afferent and efferent connectivity of the RSP is essential for comprehending the underlying mechanisms of its functions. Here, via viral tracing and fluorescence micro-optical sectioning tomography (fMOST), we systematically investigated the anatomical organisation of the upstream and downstream circuits of glutamatergic and GABAergic neurons in the dorsal and ventral RSP. The cortical connections of the RSP show laminar organisation in which the input neurons are distributed more in the deeper layers of the upstream cortex. Although different types of neurons have similar upstream circuits, GABAergic neurons show bidirectional connections with the hippocampus, whereas glutamatergic neurons only show unidirectional connections. Moreover, GABAergic neurons receive more inputs from the primary sensory cortex than from the prefrontal cortex and association cortex. The dorsal and ventral subregions have preferred circuits such that the dorsal RSP exhibits spatially topological connections with the dorsal visual cortex and lateral thalamus. The systematic study on long-range connections across RSP subregions and cell types may provide useful information for future revealing of RSP working mechanisms.https://doi.org/10.1038/s42003-025-07463-8 |
| spellingShingle | Yuxiao Li Miao Ren Bimin Liu Tao Jiang Xueyan Jia Haili Zhang Hui Gong Xiaojun Wang Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex Communications Biology |
| title | Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex |
| title_full | Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex |
| title_fullStr | Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex |
| title_full_unstemmed | Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex |
| title_short | Dissection of the long-range circuit of the mouse intermediate retrosplenial cortex |
| title_sort | dissection of the long range circuit of the mouse intermediate retrosplenial cortex |
| url | https://doi.org/10.1038/s42003-025-07463-8 |
| work_keys_str_mv | AT yuxiaoli dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT miaoren dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT biminliu dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT taojiang dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT xueyanjia dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT hailizhang dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT huigong dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex AT xiaojunwang dissectionofthelongrangecircuitofthemouseintermediateretrosplenialcortex |