Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters

Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters

Abstract RNA polymerase III (Pol III) transcribes short, essential RNAs, including the U6 small nuclear RNA (snRNA). At U6 snRNA genes, Pol III is recruited by the snRNA Activating Protein Complex (SNAPc) and a Brf2-containing TFIIIB complex, forming a pre-initiation complex (PIC). Uniquely, SNAPc a...

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Main Authors: Syed Zawar Shah, Thomas N. Perry, Andrea Graziadei, Valentina Cecatiello, Thangavelu Kaliyappan, Agata D. Misiaszek, Christoph W. Müller, Ewan P. Ramsay, Alessandro Vannini
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55553-8
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https://doi.org/10.1038/s41467-024-55553-8

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