Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality
Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/8270498 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561019378991104 |
|---|---|
| author | Trevor Simard Richard G. Jung Pouya Motazedian Pietro Di Santo F. Daniel Ramirez Juan J. Russo Alisha Labinaz Altayyeb Yousef Brijesh Anantharam Ali Pourdjabbar Benjamin Hibbert |
| author_facet | Trevor Simard Richard G. Jung Pouya Motazedian Pietro Di Santo F. Daniel Ramirez Juan J. Russo Alisha Labinaz Altayyeb Yousef Brijesh Anantharam Ali Pourdjabbar Benjamin Hibbert |
| author_sort | Trevor Simard |
| collection | DOAJ |
| description | Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and improved clinical outcomes. However, numerous challenges to modern PCI remain, namely, in-stent restenosis and stent thrombosis, underscoring the importance of understanding the vessel wall response to injury to identify targets for intervention. Among recent promising discoveries, endothelial progenitor cells (EPCs) have garnered considerable interest given an increasing appreciation of their role in vascular homeostasis and their ability to promote vascular repair after stent placement. Circulating EPC numbers have been inversely correlated with cardiovascular risk, while administration of EPCs in humans has demonstrated improved clinical outcomes. Despite these encouraging results, however, advancing EPCs as a therapeutic modality has been hampered by a fundamental roadblock: what constitutes an EPC? We review current definitions and sources of EPCs as well as the proposed mechanisms of EPC-mediated vascular repair. Additionally, we discuss the current state of EPCs as therapeutic agents, focusing on endogenous augmentation and transplantation. |
| format | Article |
| id | doaj-art-712bcf5c5ddc4b00b5efe5b024ec0151 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-712bcf5c5ddc4b00b5efe5b024ec01512025-02-03T01:26:06ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/82704988270498Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic RealityTrevor Simard0Richard G. Jung1Pouya Motazedian2Pietro Di Santo3F. Daniel Ramirez4Juan J. Russo5Alisha Labinaz6Altayyeb Yousef7Brijesh Anantharam8Ali Pourdjabbar9Benjamin Hibbert10CAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaInterventional Cardiology, University of California, San Diego, La Jolla, CA, USACAPITAL Research Group, Division of Cardiology, University of Ottawa Heart Institute, Ottawa, ON, CanadaCoronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and improved clinical outcomes. However, numerous challenges to modern PCI remain, namely, in-stent restenosis and stent thrombosis, underscoring the importance of understanding the vessel wall response to injury to identify targets for intervention. Among recent promising discoveries, endothelial progenitor cells (EPCs) have garnered considerable interest given an increasing appreciation of their role in vascular homeostasis and their ability to promote vascular repair after stent placement. Circulating EPC numbers have been inversely correlated with cardiovascular risk, while administration of EPCs in humans has demonstrated improved clinical outcomes. Despite these encouraging results, however, advancing EPCs as a therapeutic modality has been hampered by a fundamental roadblock: what constitutes an EPC? We review current definitions and sources of EPCs as well as the proposed mechanisms of EPC-mediated vascular repair. Additionally, we discuss the current state of EPCs as therapeutic agents, focusing on endogenous augmentation and transplantation.http://dx.doi.org/10.1155/2017/8270498 |
| spellingShingle | Trevor Simard Richard G. Jung Pouya Motazedian Pietro Di Santo F. Daniel Ramirez Juan J. Russo Alisha Labinaz Altayyeb Yousef Brijesh Anantharam Ali Pourdjabbar Benjamin Hibbert Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality Stem Cells International |
| title | Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality |
| title_full | Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality |
| title_fullStr | Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality |
| title_full_unstemmed | Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality |
| title_short | Progenitor Cells for Arterial Repair: Incremental Advancements towards Therapeutic Reality |
| title_sort | progenitor cells for arterial repair incremental advancements towards therapeutic reality |
| url | http://dx.doi.org/10.1155/2017/8270498 |
| work_keys_str_mv | AT trevorsimard progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT richardgjung progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT pouyamotazedian progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT pietrodisanto progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT fdanielramirez progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT juanjrusso progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT alishalabinaz progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT altayyebyousef progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT brijeshanantharam progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT alipourdjabbar progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality AT benjaminhibbert progenitorcellsforarterialrepairincrementaladvancementstowardstherapeuticreality |