Evidence for Genetic Causal Association Between the Gut Microbiome, Derived Metabolites, and Age-Related Macular Degeneration: A Mediation Mendelian Randomization Analysis

Evidence for Genetic Causal Association Between the Gut Microbiome, Derived Metabolites, and Age-Related Macular Degeneration: A Mediation Mendelian Randomization Analysis

<b>Background/Objectives</b>: Despite substantial research, the causal relationships between gut microbiota (GM) and age-related macular degeneration (AMD) remain unclear. We aimed to explore these causal associations using Mendelian randomization (MR) and elucidate the potential mechani...

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Bibliographic Details
Main Authors: Pinghui Wei, Shan Gao, Guoge Han
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomedicines
Subjects:
gut microbiota
mediation analysis
Mendelian randomization
metabolites
age-related macular degeneration
Online Access:https://www.mdpi.com/2227-9059/13/3/639
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