Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Repurposing pitavastatin and atorvastatin to overcome chemoresistance of metastatic colorectal cancer under high glucose conditions

Abstract Background Colorectal cancer (CRC) poses a significant clinical challenge because of drug resistance, which can adversely impact patient outcomes. Recent research has shown that abnormalities within the tumor microenvironment, especially hyperglycemia, play a crucial role in promoting metas...

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Main Authors: Wei-Ming Cheng, Po-Chen Li, Minh Tran-Binh Nguyen, Yu-Teng Lin, Yu-Tang Huang, Tai-Shan Cheng, Thi-Huong Nguyen, Thu-Ha Tran, Tzu-Yi Huang, Thu-Huyen Hoang, Sin-Yu Chen, Yu-Chieh Chu, Chih-Wei Wu, Ming-Fen Lee, Yi-Shiou Chiou, Hsiao-Sheng Liu, Yi-Ren Hong, Peter Mu-Hsin Chang, Yu‑Feng Hu, Ying-Chih Chang, Jin-Mei Lai, Chi-Ying F. Huang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Hyperglycemia
Drug resistance
Consensus molecular subtype
Pitavastatin
Atorvastatin
Online Access:https://doi.org/10.1186/s12935-025-03712-2
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https://doi.org/10.1186/s12935-025-03712-2

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