GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy

GP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy

Background Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of the efficacy of immunotherapy. Golgi protein 73 (GP73), a Golgi membrane protein, has been implicated in...

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Main Authors: Xiaoli Yang, Yong Li, Min Min, Nan Jiang, Lijuan Sun, Dandan Zhang, Yuan Cao, Yanhong Zhang, Yufei Wang, Hui Zhong, Xueping Ma, Qi Gao, Jialong Liu, Chao Feng, Ruzhou Zhao, Hongbin Song, Linfei Huang, Xiaopan Yang, Lanlan Liu, Cuijuan Duan, Luming Wan, Xufeng Hou, Muyi Liu, Xuemiao Zhang, Congwen Wei
Format: Article
Language:English
Published: BMJ Publishing Group 2025-01-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/1/e009265.full
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