A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure

A next-generation system for smoke inhalation integrated with a breathing lung-on-chip to model human lung responses to cigarette exposure

Abstract Continuous exposure to cigarette smoke (CS) significantly contributes to the development and progression of chronic obstructive pulmonary disease (COPD) and lung cancer. Animal models that inhale smoke nasally and have different lung physiology from humans may not accurately replicate cigar...

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Main Authors: Arunima Sengupta, Saskia Schmid, Noémie Grangier, Aurélien Dorn, Marco Hebestreit, Andreas Hugi, Kristína Žajdlíková, Anja Herbst, Paula Losada-Oliva, Heidi Ortolf-Wahl, Philippe Krebs, Janick D. Stucki, Vera van der Velpen, Jesus Perez-Gil, Tobias Krebs, Nina Hobi, Olivier T. Guenat
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Lung-on-chip
Inhalation
Cigarette smoke
Stretch
Air–liquid interface
Alveolar toxicity
Online Access:https://doi.org/10.1038/s41598-025-00438-z
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https://doi.org/10.1038/s41598-025-00438-z

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