Luteolin reduces necroptosis in the diabetic heart after cardiac arrest and resuscitation by activating sirtuin 3

Luteolin reduces necroptosis in the diabetic heart after cardiac arrest and resuscitation by activating sirtuin 3

BackgroundsMyocardial impairment resulting from cardiopulmonary resuscitation (CPR) contributes to the elevated mortality in diabetes. Luteolin, a naturally occurring polyphenolic compound abundant in vegetables, fruits, and nuts, has been shown to mitigate myocardial I/R injury in diabetes by suppr...

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Main Authors: Jin-Ting Yang, Chun-Yan Jiang, Zi-Yan Zhang, Li-Hui Tang, Yang-Yun Lou, Ling-Bo Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Nutrition
Subjects:
diabetes
post-resuscitation cardiac injury
sirtuin 3
necroptosis
mitochondria
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fnut.2025.1626020/full
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https://www.frontiersin.org/articles/10.3389/fnut.2025.1626020/full

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