E2F expression profiling-based subtypes in head and neck squamous cell carcinoma: clinical relevance, prognostic implications, and personalized therapy

E2F expression profiling-based subtypes in head and neck squamous cell carcinoma: clinical relevance, prognostic implications, and personalized therapy

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous malignancy with poor prognosis. Dysregulation of E2F transcription factors (E2Fs), which control cell proliferation and apoptosis, is implicated in HNSCC pathogenesis. This study explores HNSCC molecular heterogenei...

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Bibliographic Details
Main Authors: Huanyu Jiang, Lijuan Zhou, Haidong Zhang, Zhenkun Yu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:World Journal of Surgical Oncology
Subjects:
Head and neck squamous cell carcinoma
E2F transcription factors
Molecular classification
Tumor microenvironment
Biomarker discovery
ConsensusClusterPlus
Online Access:https://doi.org/10.1186/s12957-025-03808-z
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https://doi.org/10.1186/s12957-025-03808-z

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