MFGE8 regulates the EndoMT of HLMECs through the BMP signaling pathway and fibrosis in acute lung injury

Abstract Background To investigate the effects and mechanisms of MFGE8 on LPS-induced endothelial-to-mesenchymal transition (EndoMT) and pulmonary fibrosis in human lung microvascular endothelial cells (HLMECs) and a mouse model of acute lung injury. Methods Serum MFGE8 levels were compared between...

Full description

Saved in:
Bibliographic Details
Main Authors: Qingqiang Shi, Huang Liu, Hanghang Wang, Ling Tang, Qi Di, Daoxin Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-025-03215-8
Tags: Add Tag
No Tags, Be the first to tag this record!