Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges
Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, and cognitive dysfunction. Current pharmacological treat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1517369/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548195954065408 |
|---|---|
| author | Kamran Sheikhi Salah Ghaderi Hassan Firouzi Sarvenaz Rahimibarghani Ehsan Shabani Hamed Afkhami Hamed Afkhami Hamed Afkhami Aref Yarahmadi |
| author_facet | Kamran Sheikhi Salah Ghaderi Hassan Firouzi Sarvenaz Rahimibarghani Ehsan Shabani Hamed Afkhami Hamed Afkhami Hamed Afkhami Aref Yarahmadi |
| author_sort | Kamran Sheikhi |
| collection | DOAJ |
| description | Multiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, and cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail to arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers a promising alternative, leveraging its immunomodulatory, neuroprotective, and regenerative capabilities. This review provides an in-depth analysis of MSC mechanisms of action, including immune system regulation, promotion of remyelination, and neuroregeneration. It examines preclinical studies and clinical trials evaluating the efficacy, safety, and limitations of MSC therapy in various MS phenotypes. Special attention is given to challenges such as delivery routes, dosing regimens, and integrating MSCs with conventional therapies. By highlighting advancements and ongoing challenges, this review underscores the potential of MSCs to revolutionize MS treatment, paving the way for personalized and combinatory therapeutic approaches. |
| format | Article |
| id | doaj-art-70b98d21decb4cfb9a4c2de7f609aada |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-70b98d21decb4cfb9a4c2de7f609aada2025-02-03T06:33:54ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-02-011310.3389/fcell.2025.15173691517369Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challengesKamran Sheikhi0Salah Ghaderi1Hassan Firouzi2Sarvenaz Rahimibarghani3Ehsan Shabani4Hamed Afkhami5Hamed Afkhami6Hamed Afkhami7Aref Yarahmadi8Kurdistan University of Medical Sciences, Kurdistan, IranTabriz University of Medical Sciences, Tabriz, IranDepartment of Medical Laboratory, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, IranDepartment of Physical Medicine and Rehabilitation, Tehran University of Medical Sciences, Tehran, IranDepartment of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranCellular and Molecular Research Center, Qom University of Medical Sciences, Qom, IranNervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, IranDepartment of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, IranDepartment of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, IranMultiple sclerosis (MS), a chronic autoimmune disorder of the central nervous system (CNS), is characterized by inflammation, demyelination, and neurodegeneration, leading to diverse clinical manifestations such as fatigue, sensory impairment, and cognitive dysfunction. Current pharmacological treatments primarily target immune modulation but fail to arrest disease progression or entirely reverse CNS damage. Mesenchymal stem cell (MSC) therapy offers a promising alternative, leveraging its immunomodulatory, neuroprotective, and regenerative capabilities. This review provides an in-depth analysis of MSC mechanisms of action, including immune system regulation, promotion of remyelination, and neuroregeneration. It examines preclinical studies and clinical trials evaluating the efficacy, safety, and limitations of MSC therapy in various MS phenotypes. Special attention is given to challenges such as delivery routes, dosing regimens, and integrating MSCs with conventional therapies. By highlighting advancements and ongoing challenges, this review underscores the potential of MSCs to revolutionize MS treatment, paving the way for personalized and combinatory therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fcell.2025.1517369/fullmultiple sclerosis (MS)mesenchymal stem cell (MSC)immunomodulationautoimmune disease (AD)cell therapy |
| spellingShingle | Kamran Sheikhi Salah Ghaderi Hassan Firouzi Sarvenaz Rahimibarghani Ehsan Shabani Hamed Afkhami Hamed Afkhami Hamed Afkhami Aref Yarahmadi Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges Frontiers in Cell and Developmental Biology multiple sclerosis (MS) mesenchymal stem cell (MSC) immunomodulation autoimmune disease (AD) cell therapy |
| title | Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges |
| title_full | Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges |
| title_fullStr | Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges |
| title_full_unstemmed | Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges |
| title_short | Recent advances in mesenchymal stem cell therapy for multiple sclerosis: clinical applications and challenges |
| title_sort | recent advances in mesenchymal stem cell therapy for multiple sclerosis clinical applications and challenges |
| topic | multiple sclerosis (MS) mesenchymal stem cell (MSC) immunomodulation autoimmune disease (AD) cell therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1517369/full |
| work_keys_str_mv | AT kamransheikhi recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT salahghaderi recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT hassanfirouzi recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT sarvenazrahimibarghani recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT ehsanshabani recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT hamedafkhami recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT hamedafkhami recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT hamedafkhami recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges AT arefyarahmadi recentadvancesinmesenchymalstemcelltherapyformultiplesclerosisclinicalapplicationsandchallenges |