Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine
Bioremediation is one of the most promising methods to clean up polluted environments using highly efficient potent microbes. Microbes with specific enzymes and biochemical pathways are capable of degrading the tobacco alkaloids including highly toxic heterocyclic compound, nicotine. After the metab...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/125385 |
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| author | Raman Gurusamy Sakthivel Natarajan |
| author_facet | Raman Gurusamy Sakthivel Natarajan |
| author_sort | Raman Gurusamy |
| collection | DOAJ |
| description | Bioremediation is one of the most promising methods to clean up polluted environments using highly efficient potent microbes. Microbes with specific enzymes and biochemical pathways are capable of degrading the tobacco alkaloids including highly toxic heterocyclic compound, nicotine. After the metabolic conversion, these nicotinophilic microbes use nicotine as the sole carbon, nitrogen, and energy source for their growth. Various nicotine degradation pathways such as demethylation pathway in fungi, pyridine pathway in Gram-positive bacteria, pyrrolidine pathway, and variant of pyridine and pyrrolidine pathways in Gram-negative bacteria have been reported. In this review, we discussed the nicotine-degrading pathways of microbes and their enzymes and biotechnological applications of nicotine intermediate metabolites. |
| format | Article |
| id | doaj-art-70b96b6a30ac4380bc8506fcca80c1a3 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-70b96b6a30ac4380bc8506fcca80c1a32025-02-03T01:24:03ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/125385125385Current Status on Biochemistry and Molecular Biology of Microbial Degradation of NicotineRaman Gurusamy0Sakthivel Natarajan1Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaDepartment of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605014, IndiaBioremediation is one of the most promising methods to clean up polluted environments using highly efficient potent microbes. Microbes with specific enzymes and biochemical pathways are capable of degrading the tobacco alkaloids including highly toxic heterocyclic compound, nicotine. After the metabolic conversion, these nicotinophilic microbes use nicotine as the sole carbon, nitrogen, and energy source for their growth. Various nicotine degradation pathways such as demethylation pathway in fungi, pyridine pathway in Gram-positive bacteria, pyrrolidine pathway, and variant of pyridine and pyrrolidine pathways in Gram-negative bacteria have been reported. In this review, we discussed the nicotine-degrading pathways of microbes and their enzymes and biotechnological applications of nicotine intermediate metabolites.http://dx.doi.org/10.1155/2013/125385 |
| spellingShingle | Raman Gurusamy Sakthivel Natarajan Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine The Scientific World Journal |
| title | Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine |
| title_full | Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine |
| title_fullStr | Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine |
| title_full_unstemmed | Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine |
| title_short | Current Status on Biochemistry and Molecular Biology of Microbial Degradation of Nicotine |
| title_sort | current status on biochemistry and molecular biology of microbial degradation of nicotine |
| url | http://dx.doi.org/10.1155/2013/125385 |
| work_keys_str_mv | AT ramangurusamy currentstatusonbiochemistryandmolecularbiologyofmicrobialdegradationofnicotine AT sakthivelnatarajan currentstatusonbiochemistryandmolecularbiologyofmicrobialdegradationofnicotine |