Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis

This study aimed to detect and characterize microplastics in intervertebral disc and investigate their effects and molecular mechanism on intervertebral disc degeneration. We collected intervertebral disc tissues from cervical, lumbar, and thoracolumbar segments and used Raman spectroscopy to identi...

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Bibliographic Details
Main Authors: Weilin Zhang, Zhencong Li, Zhongwei Wang, Kuize Liu, Shengbang Huang, Jinguo Liang, Zhiwen Dai, Weixiong Guo, Chao Mao, Siyuan Chen, Jinsong Wei
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Intervertebral disc degeneration
Microplastics
Reactive oxygen species
Toll-like receptor 4
NADPH oxidase 2
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325002866
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