Porcupine inhibition is a promising pharmacological treatment for severe sclerosteosis pathologies
Abstract Sclerosteosis, an ultra-rare disorder characterised by high bone mass (HBM) and skeletal overgrowth, leads to facial paralysis, hearing loss and raised intracranial pressure, which is currently managed only through high-risk surgery. Sclerosteosis is caused by SOST mutations and loss of fun...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-04-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-025-00406-3 |
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