Convergent evolution links molybdenum insertase domains with organism-specific sequences

Abstract In all domains of life, the biosynthesis of the pterin-based Molybdenum cofactor (Moco) is crucial. Molybdenum (Mo) becomes biologically active by integrating into a unique pyranopterin scaffold, forming Moco. The final two steps of Moco biosynthesis are catalyzed by the two-domain enzyme M...

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Bibliographic Details
Main Authors: Miriam Rabenow, Eduard Haar, Katharina Schmidt, Robert Hänsch, Ralf R. Mendel, Kevin D. Oliphant
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07073-w
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